Results 241 to 250 of about 118,738 (293)

Therapeutic advances in pruritus as a model of personalized medicine

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung   +2 more
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

open access: yesJournal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer   +4 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

open access: yesJournal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó   +4 more
wiley   +1 more source

Cellular Heterogeneity Within the Solitary Tract Nucleus and Visceral Afferent Processing—Electrophysiological Approaches to Discerning Pathway Performance

open access: diamond, 2007
Michael Andresen   +5 more
openalex   +1 more source

Intramuscular tendon length in agonist–antagonist myoneural interface components in transtibial amputation: An anatomic study

open access: yesJournal of Anatomy, EarlyView.
Interestingly, this study shows that tendons spanned over 75% of the distal muscle belly in all muscles, crucial for the innovative tibiotalar agonist–antagonist myoneural interface (AMI) construction. AMI simulates natural muscle–tendon interaction in amputees, improving prosthetic control despite anatomical constraints.
Viktoria Witowski   +13 more
wiley   +1 more source

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