Results 211 to 220 of about 33,865 (256)

Potential Thyroliberin Affinity Labels II: Chloroacetyl Substituted Phenylalanyl Prolineamides

Journal of Pharmaceutical Sciences, 1982
Three analogs of thyroliberin (I) were prepared. These compounds, N-m-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIa), N-p-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIb) and N-chloroacetyl-alanyl-phenylalanyl-prolineamide (IX), were designed as potential I antagonist affinity labels.
R J, Goebel, B L, Currie, C Y, Bowers
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Affinity chromatography of fibroblast growth factors on substituted polystyrene

Journal of Chromatography B: Biomedical Sciences and Applications, 1990
The heparin-binding growth factors aFGF and bFGF (acidic and basic fibroblast growth factor) from crude bovine brain extract were co-eluted with purified [125I]aFGF and/or [125I]bFGF as tracers from heparin-Sepharose and from several insoluble substituted polystyrenes used as stationary phases in low-pressure affinity chromatography. The ability of the
M A, Dourges, D, Gulino, J, Courty, J, Badet, D, Barritault, J, Jozefonvicz   +5 more
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Electron affinities of aza-substituted polycyclic aromatic hydrocarbons

Canadian Journal of Chemistry, 1989
Electron affinities for aza-substituted polycyclic aromatics were determined from measurements of electron transfer equilibria in the dilute gas phase with a pulsed electron high pressure mass spectrometer (PHPMS). These are (in kcal/mol): quinazoline (12.7), quinoxaline (15.8), cinnoline (16.0), acridine (20.3), benzo[c]cinnoline (20.6), pyrido[2,3-b]
Glen W. Dillow, P. Kebarle
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Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2010
Pre-clinical characterization of novel substituted pyrrolidines that are high affinity histamine H(3) receptor antagonists is described. These compounds efficiently penetrate the CNS and occupy the histamine H(3) receptor in rat brain following oral administration. One compound, (2S,4R)-1-[2-(4-cyclobutyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-
Emily M, Stocking, Leah, Aluisio, John R, Atack, Pascal, Bonaventure, Nicholas I, Carruthers, Christine, Dugovic, Anita, Everson, Ian, Fraser, Xiaohui, Jiang, Perry, Leung, Brian, Lord, Kiev S, Ly, Kirsten L, Morton, Diane, Nepomuceno, Chandravadan R, Shah, Jonathan, Shelton, Akinola, Soyode-Johnson, Michael A, Letavic   +17 more
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Electrophile affinity and positional selectivity in electrophilic substitution reactions of N-substituted pyrroles

Russian Chemical Bulletin, 2011
In terms of the density functional theory (DFT) using B3LYP/6-31G(d) method with full geometry optimization, gas-phase quantum chemical calculations were performed for σ-complexes formed upon the attack of electrophiles E (E = H+, Me+, Me3Si+, Br+, NO2 +, MeCO+, SO3) on α- and β-positions of furan, thiophene, selenophene, pyrrole, and N-substituted ...
L. I. Belen’kii, N. D. Chuvylkin, I. D. Nesterov   +2 more
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The Proton Affinity of Some Substituted Naphtalenes

Journal of physical organic chemistry, 1999
The absolute proton affinity (PA) pertaining aromatic carbons of the monosubstituted naphtalenes involving CH3, OH, CHO, NO2 and Cl substituents is calculated at the MP2(fc)/6-31G**//HF/6-31G* + ZPVE(HF/6-31G*) level of theory. Increments corresponding to unsubstituted positions within the naphtalene skeleton are estimated.
Eckert-Maksić, Mirjana, Antol, Ivana, Klessinger, Martin, Maksić, Zvonimir B.   +3 more
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Relative electron affinities of substituted benzophenones, nitrobenzenes, and quinones

Journal of the American Chemical Society, 1985
On determine les affinites electroniques de 53 molecules en mesurant les constantes d'equilibre des reactions de transfert d'electron en phase gazeuse du type A −• +B=B −• +A. On utilise un spectrometre a resonance cyclotronique ionique pour generer, stocker et detecter les radicaux anioniques moleculaires a des pressions inferieures a 1×10 −5 ...
Elaine K. Fukuda, Robert T. McIver
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Synthesis and adrenoceptor affinity of some highly polar .beta.-substituted catecholamines

Journal of Medicinal Chemistry, 1981
In order to assess the potential for sympathomimetic or sympatholytic activity within the series of catecholamine beta-sulfonates 3a-c, alpha- and beta-adrenoceptor binding affinities were determined using rat brain homogenate preparations. Furthermore, their potential for indirect activity was assessed by measurement of blockade of norepinephrine ...
J G, Henkel, N, Sikand, A, Makriyannis, G, Gianutsos   +3 more
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Fibrin Affinity and Clearance of t-PA Deletion and Substitution Analogues

Thrombosis and Haemostasis, 1990
SummaryTo investigate structure-function relationships in tissue-type plasminogen activator (t-PA) we deleted the following domains in the heavy chain: a) The epidermal growth factor domain (t-PA del. G), b) the finger domain, and the epidermal growth factor domain (t-PA del. FG), and c) the finger, the epidermal growth factor and Kr-ingle 1 (1-PA del,
M, Johannessen, V, Diness, K, Pingel, L C, Petersen, D, Rao, P, Lioubin, P, O'Hara, E, Mulvihill   +7 more
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Alanine Substitutions in Calmodulin-binding Peptides Result in Unexpected Affinity Enhancement

Journal of Molecular Biology, 1996
Calmodulin is a calcium-binding protein that regulates a wide range of enzymes. It is also one of the few examples of a small protein capable of binding to peptides with very high affinity, and is therefore an interesting candidate for biotechnological applications and a good model system for studying how proteins associate.
S, Montigiani, G, Neri, P, Neri, D, Neri
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