Results 71 to 80 of about 2,193,626 (355)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Special Affine Wavelet Transforms and the Corresponding Poisson Summation Formula [PDF]

open access: yesarXiv, 2020
The special affine Fourier transform (SAFT) is a promising tool for analyzing non-stationary signals with more degrees of freedom. However, the SAFT fails in obtaining the local features of non-transient signals due to its global kernel and thereby make SAFT incompetent in situations demanding joint information of time and frequency. To circumvent this
arxiv  

Weyl Transform on Nonunimodular Groups [PDF]

open access: yesarXiv, 2023
For $p>2$, B. Simon\cite{Simon} studied the unboundedness of the Weyl transform for symbol belonging to $L^p({\mathbb{R}^n\times \mathbb{R}^n})$. In this article, we study the analog of unboundedness of the Weyl transform on some nonunimodular groups, namely, the affine group, similitude group, and affine Poincar\'e group.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Affine transformation edited and refined deep neural network for quantitative susceptibility mapping

open access: yesNeuroImage, 2023
Deep neural networks have demonstrated great potential in solving dipole inversion for Quantitative Susceptibility Mapping (QSM). However, the performances of most existing deep learning methods drastically degrade with mismatched sequence parameters ...
Zhuang Xiong   +3 more
doaj  

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

3D Convex Hull-Based Registration Method for Point Cloud Watermark Extraction

open access: yesSensors, 2019
Most 3D point cloud watermarking techniques apply Principal Component Analysis (PCA) to protect the watermark against affine transformation attacks. Unfortunately, they fail in the case of cropping and random point removal attacks.
Bogdan Lipuš, Borut Žalik
doaj   +1 more source

CAISOV: Collinear Affine Invariance and Scale-Orientation Voting for Reliable Feature Matching

open access: yesRemote Sensing, 2022
Reliable feature matching plays an important role in the fields of computer vision and photogrammetry. Due to the complex transformation model caused by photometric and geometric deformations, and the limited discriminative power of local feature ...
Haihan Luo   +5 more
doaj   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

On quasi-affine transforms of Read’s operator [PDF]

open access: yesProceedings of the American Mathematical Society, 2002
We show that C. J. Read’s example of an operator T T on ℓ 1 \ell _1 which does not have any non-trivial invariant subspaces is not the adjoint of an operator on a predual of ℓ 1 \ell _1 .
Thomas Schlumprecht   +1 more
openaire   +2 more sources

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