Results 81 to 90 of about 144,513 (307)

The Tulczyjew triple for classical fields

, 2011
The geometrical structure known as the Tulczyjew triple has proved to be very useful in describing mechanical systems, even those with singular Lagrangians or subject to constraints.
Benenti S, Campos C M Guzmán E Marrero J C, Cantrijn F, de León M, Gotay M J, Gotay M J Isenberg J Marsden J E, Gotay M J Isenberg J Marsden J E, Helein F, Katarzyna Grabowska, Kijowski J, Kijowski J, Konieczna K, Krupková O, Krupková O, Marmo G, Menzio M R, Pradines J, Rey A M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Tulczyjew W M, Vitagliano L   +26 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Generalized affine transformation monoids on Galois rings

International Journal of Mathematics and Mathematical Sciences, 2006
Let A be a ring with identity. The generalized affine transformation monoid Gaff(A) is defined as the set of all transformations on A of the form x↦xu+a (for all x∈A), where u,a∈A.
Yonglin Cao
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Optimization of Line Extraction Based on an Affine Camera Model

IEEE Access, 2019
Line feature constitutes important geometric structure information in image processing and is significant in visual navigation and 3-D structure contour extraction of 3-D objects.
Qiang Wang, Yongsheng Zhang, Yanyan Li, Zhenxin Zhang, Tiejun Cui, Lei Yan   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Center problem for quartic differential systems with an affine invariant straight line of maximal multiplicity

Acta et Commentationes: Ştiinţe Exacte şi ale Naturii
In this paper the quartic differential systems with a center-focus critical point and non-degenerate infinity are examined. We show that in this family the maximal multiplicity of an affine invariant straight line is six. Modulo the affine transformation
Olga Vacaraș
doaj   +1 more source

A Robust and Efficient Algorithm for Tool Recognition and Localization for Space Station Robot

International Journal of Advanced Robotic Systems, 2014
This paper studies a robust target recognition and localization method for a maintenance robot in a space station, and its main goal is to solve the target affine transformation caused by microgravity and the strong reflection and refraction of sunlight ...
Lingbo Cheng, Zhihong Jiang, Hui Li, Qiang Huang   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source