Results 41 to 50 of about 321,782 (311)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Gene Therapy Evidence Generation and Economic Analysis: Pragmatic Considerations to Facilitate Fit-for-Purpose Health Technology Assessment

Frontiers in Public Health, 2022
Gene therapies (GTs) are considered to be a paradigm-shifting class of treatments with the potential to treat previously incurable diseases or those with significant unmet treatment needs.
Tingting Qiu, Michal Pochopien, Shuyao Liang, Gauri Saal, Ewelina Paterak, Justyna Janik, Mondher Toumi   +6 more
doaj   +1 more source

Affordability and the Funding Gap Trends among Low-and Moderate-Income Households, 1995-2005 [PDF]

, 2007
The period between 1995 and 2005 was a tumultuous one for low- and moderate-income (LMI) households seeking to purchase their first home. A booming housing market, stagnant incomes, and low interest rates taken together have presented both opportunities ...
Doug Foster, Mark Duda
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An evaluation of rational prescribing in hospital outpatient practice in Sierra Leone and assessment of affordability of a prescription as an outcome

The Pan African Medical Journal, 2018
INTRODUCTION: Medicines are the most frequently used intervention in healthcare. Rational and cost-effective prescribing is especially important in countries where access to effective medicines may be challenged by affordability issues.
Christine Princess Cole, Philip Routledge   +1 more
doaj   +1 more source

A Permanent Problem Requires A Permanent Solution [PDF]

, 2010
Although other studies have presented data on the number of federally- and state-subsidized units that are in danger of losing their affordability, there is a lack of recognition and understanding of the magnitude of at-risk, city-subsidized units ...

core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Affordance [PDF]

Affordance describes an object or space in terms of the actions made possible for the human in the meeting of a design (or non-design) of anything. Affordance is a key concept across all scales of design, as it allows us to not only understand a site, structure, or object in terms of its physical, aesthetical, and material, properties but how these ...
Linda Nhu Laursen, Ole B. Jensen, Markus Löchtefeld   +2 more
  +4 more sources

Assessing the acceptability, affordability, and availability of teleoncology services among cancer patients: A cross-sectional study

Journal of Family Medicine and Primary Care
Context: With the increasing burden of cancer and the need for continuous patient monitoring, teleoncology has emerged as an innovative approach to improve healthcare delivery.
Praveen Suthar, Swati Kharbanda, Nitin Kumar Joshi, Komal Parmar, Parthasarathi Ganguly   +4 more
doaj   +1 more source

Rising Student Debt and the 2020 Election [PDF]

, 2020
In this perspectives brief, authors James Kvaal and Jessica Thompson explore the challenge of college affordability and summarize the campaign proposals to address it.
Kvaal, James, Thompson, Jessica
core   +1 more source