Results 61 to 70 of about 641,442 (338)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Affordance [PDF]

Affordance describes an object or space in terms of the actions made possible for the human in the meeting of a design (or non-design) of anything. Affordance is a key concept across all scales of design, as it allows us to not only understand a site, structure, or object in terms of its physical, aesthetical, and material, properties but how these ...
Linda Nhu Laursen, Ole B. Jensen, Markus Löchtefeld   +2 more
  +4 more sources

Grounding human-object interaction to affordance behavior in multimodal datasets

Frontiers in Artificial Intelligence, 2023
While affordance detection and Human-Object interaction (HOI) detection tasks are related, the theoretical foundation of affordances makes it clear that the two are distinct. In particular, researchers in affordances make distinctions between J.
Alexander Henlein, Anju Gopinath, Nikhil Krishnaswamy, Alexander Mehler, James Pustejovsky   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ICT-based Learning Personalization Affordance in the Context of Implementation of Constructionist Learning Activities

Informatics in Education, 2015
How to enable students to create a personalized learning environment? What are the criteria of evaluation of the ICT-based learning process personalization affordance?
Natalija IGNATOVA, Valentina DAGIENĖ, Svetlana KUBILINSKIENĖ   +2 more
doaj   +1 more source

Travel live streaming: an affordance perspective

Information Technology & Tourism, 2021
This study draws on tourism literature and current examples to propose that the emergence of Travel Live Streaming (TLS) provides new affordances for live streamers, viewers, and sponsors.
Zhiming Deng, P. Benckendorff, Jie Wang
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Reduced processing of afforded actions while observing mental content as ongoing mental phenomena

Scientific Reports
While consciousness is typically considered equivalent to mental contents, certain meditation practices—including open monitoring (OM)—are said to enable a unique conscious state where meditators can experience mental content from a de-reified ...
Sucharit Katyal, Oussama Abdoun, Hugues Mounier, Antoine Lutz   +3 more
doaj   +1 more source

Training-Free Affordance Labeling and Exploration Using Subspace Projection and Manifold Curvature Over Pre-Trained Deep Networks

IEEE Access
The advancement in computing power has significantly reduced the training times for deep learning, enabling the rapid development of networks designed for object recognition.
Ismail Ozcil, A. Bugra Koku
doaj   +1 more source

Embodied Perception: A Proposal to Reconcile Affordance and Spatial Perception

i-Perception, 2015
Proffitt's embodied approach to perception is deeply indebted to Gibson's ecological approach to visual perception, in particular the idea that the primary objects of perception are affordances or what the environment offers for action.
Rouwen Cañal-Bruland, John van der Kamp
doaj   +1 more source