Results 61 to 70 of about 56,722 (292)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Examining Generative AI User Disclosure Intention: A Perceived Affordance Perspective

Journal of Theoretical and Applied Electronic Commerce Research
Generative AI needs to collect user data to provide more accurate answers. This may raise users’ privacy concern and undermine their disclosure intention.
Tao Zhou, Xiaoying Wu
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Chained activation of the motor system during language understanding [PDF]

, 2017
Two experiments were carried out to investigate whether and how one important characteristic of the motor system, that is its goal-directed organization in motor chains, is reflected in language processing. This possibility stems from the embodied theory
Borghi, ANNA MARIA, Buccino, Giovanni, Marino, Barbara F, Riggio, Lucia   +3 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Reduced processing of afforded actions while observing mental content as ongoing mental phenomena

Scientific Reports
While consciousness is typically considered equivalent to mental contents, certain meditation practices—including open monitoring (OM)—are said to enable a unique conscious state where meditators can experience mental content from a de-reified ...
Sucharit Katyal, Oussama Abdoun, Hugues Mounier, Antoine Lutz   +3 more
doaj   +1 more source

Training-Free Affordance Labeling and Exploration Using Subspace Projection and Manifold Curvature Over Pre-Trained Deep Networks

IEEE Access
The advancement in computing power has significantly reduced the training times for deep learning, enabling the rapid development of networks designed for object recognition.
Ismail Ozcil, A. Bugra Koku
doaj   +1 more source

Embodied Perception: A Proposal to Reconcile Affordance and Spatial Perception

i-Perception, 2015
Proffitt's embodied approach to perception is deeply indebted to Gibson's ecological approach to visual perception, in particular the idea that the primary objects of perception are affordances or what the environment offers for action.
Rouwen Cañal-Bruland, John van der Kamp
doaj   +1 more source

The personal created through dialogue: enhancing possibilities through the use of new media [PDF]

, 2005
This paper explores the relationships between a number of different developments in higher education pedagogy, which are subsumed under the broad heading of progress files.
Clegg, Sue, Hudson, Alison, Mitchell, Andy   +2 more
core   +2 more sources