Results 41 to 50 of about 63,052 (289)

Magnetic and multistable: reinterpreting the affordances of educational technology

open access: yesInternational Journal of Educational Technology in Higher Education, 2018
The concept of affordances has become a popular analytical tool in educational technology. The present article, however, argues that the current understanding of affordances does not adequately address the use of educational technology and instead ...
Jesper Aagaard
doaj   +1 more source

Boundaryless Twitter Use: On the Affordances of Social Media

open access: yesSocial Sciences, 2020
For this study, we followed the director general (DG) of a large Swedish public authority on Twitter. We analyzed the data from Twitter and from interviews in terms of four affordances that distinguish social media from more traditional technologies ...
Steffi Siegert   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A new paradigm to study social and physical affordances as model-based reinforcement learning

open access: yesCognitive Robotics
Social affordances, although key in human-robot interaction processes, have received little attention in robotics. Hence, it remains unclear whether the prevailing mechanisms to exploit and learn affordances in the absence of human interaction can be ...
Augustin Chartouny   +3 more
doaj   +1 more source

ICT multimedia learning affordances: role and impact on ESL learners' writing accuracy development

open access: yesHeliyon, 2021
This work examined the role and impact of Information and Communications Technology (ICT) tools such as YouTube as an open educational resource-cum-tool with respect to its affordances of captions and their adjustable settings like font size and color (i.
Azzam Alobaid
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Stable and variable affordances are both automatic and flexible

open access: yesFrontiers in Human Neuroscience, 2015
The mere observation of pictures or words referring to manipulable objects is sufficient to evoke their affordances since objects and their nouns elicit components of appropriate motor programs associated with object interaction. While nobody doubts that
Anna M Borghi, Lucia eRiggio
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Review of Activist Affordances: How Disabled People Improvise More Habitable Worlds by Arseli Dokumacı (Duke University Press)

open access: yesLateral
Activist Affordances: How Disabled People Improvise More Habitable Worlds by Arseli Dokumacı builds upon theories of affordances through the concept of “activist affordances,” which describes the “performative microacts/-arts through which disabled ...
Emalee Crews
doaj   +1 more source

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