Results 51 to 60 of about 24,071 (243)

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran, Ali Koskela, Hanna Heloterä, Kai Kaarniranta   +3 more
wiley   +1 more source

Multiple criteria decision analysis in the context of health technology assessment: a simulation exercise on metastatic colorectal cancer with multiple stakeholders in the English setting [PDF]

, 2017
Background: Multiple criteria decision analysis (MCDA) has appeared as a methodology to address limitations of economic evaluation in health technology assessment (HTA), however there are limited empirical evidence from real world applications.
Angelis, Aris, Hochhauser, Daniel, Kanavos, Panos, Montibeller, Gilberto   +3 more
core   +2 more sources

Outcomes and costs of Ranibizumab and Aflibercept treatment in a health-service research context

BMC Ophthalmology, 2018
Background To compare anti-VEGF treatments for macular disease in terms of costs and clinical outcomes. Methods We identified patients suffering from macular disease and treated either with aflibercept, ranibizumab or both at the largest public eye ...
Martin K. Schmid, Oliver Reich, Eva Blozik, Livia Faes, Nicolas S. Bodmer, Silvan Locher, Michael A. Thiel, Roland Rapold, Maximilian Kuhn, Lucas M. Bachmann   +9 more
doaj   +1 more source

Interventions for submacular haemorrhage: A systematic review and network meta‐analysis of controversies—On behalf of the Spanish Vitreo‐Retinal Society (SERV)

Acta Ophthalmologica, EarlyView.
Abstract Purpose This systematic review aims to evaluate and synthesize the existing literature on the interventions used for submacular haemorrhage (SMH), highlighting the controversies and differences in clinical practice. Method A systematic review was conducted following the PRISMA guidelines.
Salvador Pastor‐Idoate, Pablo Redruello‐Guerrero, Laura de Juan Hernández, Gregorio Benites‐Narcizo, Mario Rivera‐Izquierdo, José García‐Arumí, José Carlos Pastor Jimeno   +6 more
wiley   +1 more source

EFFICACY OF INTRAVITREAL AFLIBERCEPT IN MACULAR TELANGIECTASIA TYPE 1 IS LINKED TO THE OCULAR ANGIOGENIC PROFILE. [PDF]

, 2017
To evaluate intravitreal aflibercept in macular telangiectasia Type 1 (MacTel 1) patients and measure their ocular angiogenic profile. Eight subjects with MacTel 1 refractory to bevacizumab, ranibizumab, or laser therapy and switched to aflibercept were ...
Autiero, Brown, Cahill, Cai, Cao, Charbel Issa, Charbel Issa, Christoforidis, Ciarnella, Daruich, Do, Fan, Ferrara, Fischer, Fischer, Gaillard, Gamulescu, Gass, Gass, He, Heier, Kase, Kearney, Kinge, Koay, Kovach, Kowalczuk, Krohne, Kupitz, Loutfi, Matet, Matsumoto, Miyamoto, Moisseiev, Moon, Muether, Noma, Noma, Odorisio, Okamoto, Papadopoulos, Priglinger, Rahimy, Roller, Rouvas, Shibeeb, Shibuya, Sigler, Smithen, Stewart, Takayama, Weickhardt, Witmer, Wolanska, Yannuzzi, Yonekura, Zhang   +56 more
core   +2 more sources

SD‐OCT‐based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti‐VEGF therapy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the role of spectral domain optical coherence tomography (SD‐OCT)‐based biomarkers in predicting treatment response of macular oedema (MO) secondary to retinal vein occlusion (RVO) to anti‐vascular endothelial growth factor (VEGF) therapy.
Ken K. Tsang, Vivian W. K. Hui, Christopher M. K. Pang, Ziqi Tang, Dawei Yang, Truong X. Nguyen, Shaheeda Mohamed, Timothy Y. Y. Lai, Carol Y. Cheung, Simon K. H. Szeto   +9 more
wiley   +1 more source

Real‐world outcomes of aflibercept 8 mg in patients previously treated for neovascular age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age‐related macular degeneration (nAMD). Methods This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti‐VEGF therapies at Sahlgrenska University Hospital between February 2024 and ...
Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund   +5 more
wiley   +1 more source

Relevance of indirect comparisons in the German early benefit assessment and in comparison to HTA processes in England, France and Scotland [PDF]

, 2014
Early benefit assessment in Germany under the legislative framework of AMNOG (Arzneimittelmarktneuordnungsgesetz) requires direct comparisons of the new drug with appropriate comparators determined by the Federal Joint Committee (G-BA).
Dippel, Franz-Werner, Gasche, David, Lebioda, Andrea, Plantör, Stefan, Theobald, Karlheinz   +4 more
core   +1 more source

Fixed Quarterly Dosing of Aflibercept after Loading Doses in Neovascular Age-Related Macular Degeneration in Chinese Eyes [PDF]

, 2023
Daniel H. T. Wong, Kenneth K. W. Li
openalex   +1 more source

Neovascular age‐related macular degeneration without drusen

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks, Elon H. C. van Dijk, Husein Ghalayini, Somayeh Bazdar, WeiFeng Yu, Suzanne Yzer, José P. Martinez Ciriano, Reinier O. Schlingemann, Roselie M. H. Diederen, Camiel J. F. Boon   +9 more
wiley   +1 more source