Results 31 to 40 of about 274,867 (212)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Fostering Entrepreneurship Education within South African Higher Education
Journal of Economics Education and EntrepreneurshipThe paper explores the imperative of fostering entrepreneurship education within the context of South African higher education. The escalating unemployment rate in South Africa caused by economic challenges necessitates sustainable pathways to alleviate ...
Sharon Dipolelo Mmakola +1 more
doaj +1 more source
Making room for alternative African epistemologies in Ethiopian higher education
Bahir Dar Journal of Education, 2023 Higher education institutions in Ethiopia are expanding in diversity of fields they offer to students at the undergraduate and graduate levels. The opening and internationalization of new programs mostly responds to the demands of market forces on the ...
Meskerem Lechissa Debele
doaj +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Realizing Fee-Free Higher Education in South Africa; Dreams and Nightmares
The Journal of Quality in Education, 2022 The component of free rudimentary education is guaranteed and recognized by the 1996 Constitution, the African National Congress (ANC) Freedom Charter as well as other international instruments such as the Universal Declaration of Human Rights (UDHR ...
Isaiah Mmatipe Sefoka
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Transformation in Higher EducationThis article uses the findings obtained from a study that delves into the perceptions of students on their relationship with their higher education (HE) lecturers and how it affects their academic success, to respond to the issue of decolonisation in ...
Felix I. Okoye
doaj +1 more source
African female doctoral graduates account for success in their doctoral journeys
HTS Teologiese Studies/Theological Studies, 2022 Doctoral education is regarded as a crucial engine for development by the knowledge economies, thereby making the research capacity of scholars play a critical factor towards development.
Lifutso Tsephe, Cheryl Potgieter
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source