Results 31 to 40 of about 18,832 (221)

6. African swine fever vaccines

, 2021
Review of African swine fever virus vaccines as of 2021 African swine fever virus causes an acute haemorrhagic fever in domestic pigs and wild boar which is invariably fatal. Introduction of the disease into Georgia in 2007 has led to the deaths of tens
C.L. Netherton, Netherton, Christopher L
core   +1 more source

Clinical Validation of Two Recombinase-Based Isothermal Amplification Assays (RPA/RAA) for the Rapid Detection of African Swine Fever Virus

Frontiers in Microbiology, 2020
African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating infectious disease of domestic pigs and wild boars, and has tremendous negative socioeconomic impact on the swine industry and food security worldwide.
Xiaoxu Fan, Lin Li, Yonggang Zhao, Yutian Liu, Chunju Liu, Qinghua Wang, Yaqin Dong, Shujuan Wang, Tianying Chi, Fangfang Song, Chengyou Sun, Yingli Wang, Dengchuriya Ha, Yang Zhao, Yang Zhao, Jingyue Bao, Xiaodong Wu, Zhiliang Wang   +17 more
doaj   +1 more source

Novel P22-monoclonal antibody based blocking ELISA for the detection of African swine fever virus antibodies in serum

Biosafety and Health, 2022
African swine fever (ASF) is a highly infectious, transboundary viral disease of domestic and wild pigs, and is currently the most serious threat to world swine production, resulting in significant economic loss. In the absence of vaccines and treatments,
Ghebremedhin Tsegay, Weldu Tesfagaber, Yuanmao Zhu, Xijun He, Wan Wang, Zhenjiang Zhang, Encheng Sun, Jinya Zhang, Yuntao Guan, Fang Li, Renqiang Liu, Zhigao Bu, Dongming Zhao   +12 more
doaj   +1 more source

African swine fever virus – variants on the rise [PDF]

, 2022
African swine fever virus (ASFV), a large and complex DNA-virus circulating between soft ticks and indigenous suids in sub-Saharan Africa, has made its way into swine populations from Europe to Asia.
Deutschmann, Paul, Hellert, Jan, Martin Beer, Thulke, Hans-Hermann, Forth, Jan H., Forth, Jan Hendrik, Lange, Martin, Jan H. Forth, Paul Deutschmann, Adam Reichold, Julia Sehl-Ewert, Roszyk, Hanna, Svitlana Mandyhra, Fischer, Melina, Martin Lange, Maryna Sapachova, Carola Sauter-Louis, Hanna Roszyk, Melina Fischer, Hans-Hermann Thulke, Höper, Dirk, Blome, Sandra, Sandra Blome, Sapachova, Maryna, Sten Calvelage, Mandyhra, Svitlana, Sehl-Ewert, Julia, Beer, Martin, Jan Hellert, Dirk Höper, Sauter-Louis, Carola, Reichold, Adam, Calvelage, Sten   +32 more
core   +1 more source

Evaluation of Haematological and Immunological Parameters of the ASFV Lv17/WB/Rie1 Strain and Its Derived Mutant Lv17/WB/Rie1/d110-11L against ASFV Challenge Infection in Domestic Pigs

Vaccines, 2023
African swine fever virus (ASFV) is the etiological agent of a haemorrhagic disease that threatens the global pig industry. There is an urgency to develop a safe and efficient vaccine, but the knowledge of the immune–pathogenetic mechanisms behind ASFV ...
Giulia Franzoni, Stefano Petrini, István Mészáros, Silvia Dei Giudici, Cecilia Righi, Ferenc Olasz, Susanna Zinellu, Vivien Tamás, Michela Pela, Carmina Gallardo, Zoltán Zádori, Annalisa Oggiano, Francesco Feliziani   +12 more
doaj   +1 more source

Unpicking the Secrets of African Swine Fever Viral Replication Sites

Viruses, 2021
African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral ...
Sophie-Marie Aicher, Paul Monaghan, Christopher L. Netherton, Philippa C. Hawes   +3 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

African Swine Fever Virus (ASFV): Immunity and Vaccine Development

, 2023
African swine fever virus (ASFV) is the causative agent of the highly contagious disease African swine fever (ASF), which can result in mortality rates of up to 100% in pigs infected by virulent strains [...
Jong-Soo Lee (194708), Kiramage Chathuranga (7245233)   +1 more
core   +2 more sources

African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation

Veterinary Research
African swine fever virus (ASFV) is a DNA virus that has significantly impacted the global swine industry. Currently, there are no effective therapies or vaccines against ASFV.
Han Gao, Taoming Gu, Xiaopeng Gao, Zebu Song, Jing Liu, Yi Song, Guihong Zhang, Yankuo Sun   +7 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source