Results 31 to 40 of about 1,974 (222)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Book review: learning from the curse: Sembene's Xala by Richard Fardon and Senga la Rouge [PDF]

open access: yes, 2017
Dagna Rams highlights the many uses of ‘Learning from the curse’: a fun and off-beat reportage of the place and the time, a film club companion for solitary viewers, and also a book to admire ...
Rams, Dagna
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Mazrui and His Critics

open access: yesAmerican Journal of Islam and Society, 2005
This work is a review essay of two books: Africanity Redefined: Collected Essays of Ali A. Mazrui, edited by Ali Alamin Mazrui, Ricardo Rene Laremont, Tracia Leacock Seghatolislami, Michael A.
Paul Banahene Adjei
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Theological education in tropical Africa: An essay in honour of Christina Landman and a Kenyan perspective

open access: yesHTS Teologiese Studies/Theological Studies, 2019
Christina Landman is a professor of Theology at the Research Institute for Theology and Religion, University of South Africa. As an East African serving under her as a research fellow at the Research Institute of Theology and Religion since 2014, and as ...
Julius M. Gathogo
doaj   +1 more source

Politics and street trading in Africa: Developing a comparative frame. [PDF]

open access: yes, 2017
Street trading is ubiquitous in African cities, but despite research over the last 40 years, there has been relatively little analysis of the political factors that influence the street economy.
Brown, Alison, Mackie, Peter
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

African Pygmies [PDF]

open access: yesCurrent Biology, 2016
Paul Verdu introduces the anthropology and genetics of African populations often summarised under the label 'Pygmy'.
openaire   +3 more sources

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