Results 81 to 90 of about 30,636 (221)

High afterload rather than myocardial fibrosis predicts reduced ejection fraction in severe aortic stenosis with afterload mismatch

open access: yesOpen Heart
Background Afterload mismatch (AM) refers to high-gradient (mean gradient ≥40 mm Hg) severe aortic stenosis (AS) with reduced left ventricular ejection fraction (LVEF <50%) that is hypothesised to arise from mechanisms other than true contractile ...
Anton Doubell   +2 more
doaj   +1 more source

Presentation of preload and afterload to isolated heart preparations

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The heart can be isolated, and when this is so, it must be subjected to loading conditions. Over the past few decades, various loading methods have been developed to prescribe preload and afterload to isolated working‐heart preparations.
Esau Mhandu   +4 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Special Statement: Checklist for initial management of amniotic fluid embolism—Updated 2026

open access: yesPregnancy, Volume 2, Issue 5, September 2026.
Abstract Amniotic fluid embolism is a rare syndrome characterized by sudden cardiorespiratory collapse during labor or soon after delivery. Because of its rarity, many obstetrical providers have no experience in managing amniotic fluid embolism and may therefore benefit from a cognitive aid such as a checklist.
Society for Maternal‐Fetal Medicine (SMFM)   +6 more
wiley   +1 more source

Septic cardiomyopathy: evidence for a reduced force-generating capacity of human atrial myocardium in acute infective endocarditis

open access: yesInnovative Surgical Sciences, 2017
This study analyzes the myocardial force-generating capacity in infective endocarditis (IE) using an experimental model of isolated human atrial myocardium.
Buschmann Katja   +6 more
doaj   +1 more source

PKA‐Mediated Proteasome Activation Protects Against Cardiac Remodeling and Heart Failure During Systolic Overload

open access: yesThe FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Systolic overload increases the synthesis of cardiac proteins, both misfolded and native, leading to cardiac hypertrophy and elevated proteostasis burden. Meanwhile, systolic overload also increases Ser14‐RPN6 phosphorylation (pS14‐RPN6), thereby increasing proteasome (Psm) proteolytic capacity and meeting the increased demand for protein degradation ...
Md. Salim Ahammed   +7 more
wiley   +1 more source

Cerebrovascular Events in Aortic Stenosis: From Native Valve Disease to TAVR‐Specific Risk and Prevention

open access: yesCatheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 331-342, August 1, 2026.
ABSTRACT Aortic stenosis (AS) is associated with a heightened burden of cardiovascular comorbidities, atrial fibrillation (AF), and progressive valvular calcification, all of which may contribute to cerebrovascular events across the disease continuum.
Priyanka Boettger   +7 more
wiley   +1 more source

Impella‐Assisted High‐Risk Percutaneous Coronary Intervention in Cardiogenic Shock With Low‐Flow, Low‐Gradient Aortic Stenosis and Multivessel Coronary Artery Disease: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Patients with cardiogenic shock, low‐flow, low‐gradient aortic stenosis, and multivessel coronary artery disease who are ineligible for surgery present a major therapeutic challenge. Percutaneous mechanical circulatory support may facilitate revascularization in this high‐risk population. A 69‐year‐old man presented after a mechanical fall and
Douni Roger   +3 more
wiley   +1 more source

The Immuno‐Cardiovascular Storm of Pre‐Eclampsia: Cytokine‐Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular‐Left Atrial Axis Abnormalities

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Compared to traditional cardiometabolic comorbidities, COPD and atrial fibrillation are uniquely linked to pulmonary vascular remodeling in HFpEF. The impact of these two comorbidities on pulmonary vascular‐left atrial axis is highlighted by the shared biventricular morphology among HFpEF subgroups.
Mariana Garcia‐Arango   +20 more
wiley   +1 more source

Assessment of Pulmonary Vascular Impedance in Patients With Severe Pulmonary Arterial Hypertension

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Pulmonary vascular impedance (PVZ) was calculated from clinical PA pressure and RVOT flow velocity profiles. Participants with increased pulmonary vascular resistance have increased PVZ, afterload, and diastolic stiffness. The characteristic impedance (ZC) to mean PA pressure relationship models the effect of proximal vasculature remodeling on ZC for a
Keeley Shea Ravellette   +7 more
wiley   +1 more source

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