Results 131 to 140 of about 4,246,910 (248)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Age‐related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields

, 2020
Shauna M. Stark, Amy Frithsen, Craig E.L. Stark   +2 more
openalex   +2 more sources

A Healthy Dietary Pattern at Midlife, Combined with a Regulated Energy Intake, Is Related to Increased Odds for Healthy Aging [PDF]

, 2015
Karen E. Assmann, Camille Lassale, Valentina A. Andreeva, Claude Jeandel, Serge Herçberg, Pilar Galán, Emmanuelle Kesse‐Guyot   +6 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparison of treat-and-extend (T&E) dosing regimens and visual outcomes in the ARIES and ALTAIR studies of intravitreal aflibercept (IVT-AFL) in neovascular age-related macular degeneration (nAMD)

, 2020
Paul Mitchell, Frank G. Holz, Philip Hykin, Edoardo Midena, Annabelle A. Okada, Eric H. Souied, Kanji Takahashi, Sebastián Wolf, Helmut Allmeier, George Ι. Lambrou, Thomas Schmelter, Masahito Ohji   +11 more
openalex   +1 more source

Multidimensional Risk Factors of Age-Related Hearing Loss Among Malaysian Community‐Dwelling Older Adults

, 2021
Ooi TC, Ishak WS, Rumaysa Sharif, S Shahar, Rajab NF, Singh DKA, Mukari SZMS   +6 more
openalex   +1 more source

APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway

, 2020
Yiwen Sun, Ruixia Song, Yanliang Ai, Jianjun Zhu, Jun He, Minyan Dang, Hui Li   +6 more
openalex   +1 more source

Curcumin Inhibits Age-Related Vascular Changes in Aged Mice Fed a High-Fat Diet [PDF]

, 2018
Kenichiro Takano, Junko Tatebe, Naohiro Washizawa, Toshisuke Morita   +3 more
openalex   +1 more source

Sedentary Behaviors, Sleep, and Health-related Quality of Life in Middle-aged Adults

, 2021
Yen T. Chen, Carole K. Holahan, Darla M. Castelli   +2 more
openalex   +2 more sources