Results 91 to 100 of about 17,828,039 (353)

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

UVA: A Universal Variational Framework for Continuous Age Analysis [PDF]

arXiv, 2019
Conventional methods for facial age analysis tend to utilize accurate age labels in a supervised way. However, existing age datasets lies in a limited range of ages, leading to a long-tailed distribution. To alleviate the problem, this paper proposes a Universal Variational Aging (UVA) framework to formulate facial age priors in a disentangling manner.
arxiv  

A method to estimate stellar ages from kinematical data [PDF]

, 2018
We present a method to build a probability density function (pdf) for the age of a star based on its peculiar velocities $U$, $V$ and $W$ and its orbital eccentricity. The sample used in this work comes from the Geneva-Copenhagen Survey (GCS) which contains both the spatial velocities, orbital eccentricities and isochronal ages for about $14\,000 ...
arxiv   +1 more source

Grounded Theory Methodology: Positivism, Hermeneutics, and Pragmatism [PDF]

, 2011
Glaserian grounded theory methodology, which has been widely adopted as a scientific methodology in recent decades, has been variously characterised as hermeneutic and positivist. This commentary therefore takes a different approach to characterising
Age, Lars-Johan
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay

Alzheimer’s Research & Therapy
Background Plasma p-tau217 has emerged as the most promising blood-based marker (BBM) for the detection of Alzheimer Disease (AD) pathology, yet few studies have evaluated plasma p-tau217 performance in memory clinic settings. We examined the performance
Adam H. Dyer, Helena Dolphin, Antoinette O’Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O’Farrelly, Aoife Fallon, Sean O’Dowd, Nollaig M. Bourke, Sean P. Kennelly   +24 more
doaj   +1 more source

The Essential Function of the MRN Complex in the Resolution of Endogenous Replication Intermediates

Cell Reports, 2014
The MRN complex (Mre11/Rad50/Nbs1) is important in double-strand break (DSB) recognition, end resection, replication fork stabilization, and ATM and ATR activation.
Christopher Bruhn, Zhong-Wei Zhou, Haiyan Ai, Zhao-Qi Wang   +3 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

On Modulo AG-groupoids [PDF]

arXiv, 2014
A groupoid G is called an AG-groupoid if it satisfies the left invertive law: (ab)c = (cb)a. An AG-group G, is an AG-groupoid with left identity e \in G (that is, ea = a for all a \in G) and for all a \in G there exists a' \in G such that a.a' = a'.a = e.
arxiv  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source