Results 151 to 160 of about 19,513,995 (333)

Technology readiness among UK-based cognitively unaffected older adults during the COVID-19 pandemic: potential implications for decentralised alzheimer’s disease prevention trials

BMC Geriatrics
Background Alzheimer’s disease (AD) remains a global health and socioeconomic burden. Telemedicine has been more widely used since the beginning of the COVID-19 pandemic and may be an effective strategy to mitigate the rising costs associated with AD ...
S. Taylor, L. Dunn, C. Udeh-Momoh, K. Abbott, P. Giannakopoulou, L. Middleton, O. Robinson, J. Kalsi, D. Kafetsouli, J. Ford   +9 more
doaj   +1 more source

Aging [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1997
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Age as a Differential Factor of the Activity of Disabled People in the Rural Areas of the Lubelskie Voivodship

, 2013
Wiesław Romanowicz, Józef Bergier, Dorota Tomczyszyn   +2 more
openalex   +2 more sources

Review for "Male‐female ratios in autism spectrum disorders by age, intellectual disability and attention deficit/hyperactivity disorder"

, 2021

openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Rune J. Sørensen: En effektiv offentlig sektor: Organisering, styring og ledelse i stat og kommune

Tidsskrift for Samfunnsforskning, 2010
Åge Johnsen
doaj   +1 more source

Aging

Experimental Animals, 2021
openaire   +3 more sources