Results 221 to 230 of about 19,513,995 (333)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deep Learning for Age Estimation and Sex Prediction Using Mandibular-Cropped Cephalometric Images: Comparative Model Development and Validation Study. [PDF]

JMIR AI
Handayani VW, Margaretha Amiatun Ruth MS, Rulaningtyas R, Kurniawan A, Yudhantorro BA, Yudianto A.   +5 more
europepmc   +1 more source

Modeling of Water Age in the Drinking Water Distribution System of Trondheim Kommune

, 2020
Jon Kristian Rakstang
openalex   +1 more source

POPULATION CHANGES AMONG AGED PEOPLE IN THE PREFECTURE OF LONG LIFE AND IN THAT OF SHORT LIFE

, 1960
Koki Abe, KUNIO YANO, MASATANE MORIYAMA, MATUO MIZOBE, Toshiharu Furukawa   +4 more
openalex   +2 more sources

A influência da religião e da espiritualidade na qualidade de vida dos idosos institucionalizados = La influencia de la religión y de la espiritualidad en la calidad de vida, en mujeres de edad avanzada en hogares de tercera edad, en la región de Lisboa y el Valle del Tajo en Portugal = The influence of religion and spirtuality on the quality of life, in women of advanced age in third-age homes, in the region of Lisbon and the Valley of the Tajo in Portugal [PDF]

, 2019
Ana Filipa Dos Santos Cachado Peres
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Predicting brain volumes from anthropometric and demographic features: insights from UK biobank neuroimaging data. [PDF]

Brain Struct Funct
Nazarzadeh K, Eickhoff SB, Antonopoulos G, Hensel L, Tscherpel C, Komeyer V, Raimondo F, Grefkes C, Patil KR.   +8 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Bias and generalizability of brain age prediction models: A multi-cohort evaluation with anatomical and interpretability insights. [PDF]

Imaging Neurosci (Camb)
Aguzin Parrilli LJ, Belzunce MA.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source