Association between younger-onset type 2 diabetes and long-term risk of CVD events: a 34-year follow-up of the Da Qing Diabetes Prevention Study. [PDF]
Shen X +10 more
europepmc +1 more source
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Burden of disease for multiple myeloma in China and the Asia-Pacific region, 1990-2021: a systematic analysis of the Global Burden of Disease (GBD) 2021 study. [PDF]
Wang SX, Luo T, Yang N, Liu XR, Ma YP.
europepmc +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Divergent Trajectories and Risk Factor Attribution of Chronic Obstructive Pulmonary Disease Burden in China and the United States, 1990-2023: An Age-Period-Cohort Analysis with Projections to 2035 Based on the Global Burden of Disease Study 2023. [PDF]
Deng Y, Zhu Y, Chen C, Xu W, Yao W.
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The Permission Paradox: Condoning Deception Can Promote Honesty in Young Children. [PDF]
Tan C, Ding XP, Heyman GD.
europepmc +1 more source

