Results 281 to 290 of about 19,413,831 (333)

The effect of age on third molar extraction difficulty: a retrospective cross-sectional cohort study. [PDF]

Acta Odontol Scand
Noro A, Snäll J, Ventä I.
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

A Long-Term Projection for Emergency Ambulance Services Demand in Taipei and the Related Effects by Temperature. [PDF]

Emerg Med Int
Wong HT, Nguyen TD.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Global burden of non-Hodgkin lymphoma in the elderly: a population-based study using GBD 2021. [PDF]

Ann Hematol
Wang Y, Chen J, Guo J, Song Y, Zhu J, Ma J, Zhou M, Qi J, Liu W.   +8 more
europepmc   +1 more source

Gastroenteropancreatic Neuroendocrine Tumor Incidence by Sex and Age in the US

Yazan Abboud, Anand Shah, Riya Sutariya, Vraj P. Shah, Ahmed Al‐Khazraji, Paul J. Gaglio, Kaveh Hajifathalian   +6 more
openalex   +2 more sources

Inverse Associations of Acetic Acid Intake with Carbohydrate, Sugar, and Saturated Fat Intakes Among Japanese Adults Aged 20 to 69 Years. [PDF]

Nutrients
Yamamoto-Wada R, Yoshimoto J, Kodaira Y, Deguchi K, Aoki Y, Kishi M, Iizuka K.   +6 more
europepmc   +1 more source