Results 101 to 110 of about 2,694,408 (308)

Calibration of White Dwarf cooling sequences: theoretical uncertainty

, 2002
White Dwarf luminosities are powerful age indicators, whose calibration should be based on reliable models. We discuss the uncertainty of some chemical and physical parameters and their influence on the age estimated by means of white dwarf cooling ...
Clemens J. C., De Witt H., D’Antona F., Kippenhahn R., Kippenhahn R., Mestel L., Oscar Straniero, Pier Giorgio Prada Moroni, Potekhin A. Y., Potekhin A. Y., Stolzmann W., Straniero O., Von Hippel T., Weidemann V., Weidemann V., Weidemann V., Yakovlev D.   +16 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Age Distribution, Saving and Consumption in Sweden [PDF]

This paper focuses on an empirical analysis of the dependency between age structure and aggregate consumption and the composition of aggregate savings.
Berg, Lennart
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Radiomic‐based biomarkers: Transforming age and body composition metrics into personalized age‐informed indices

Clinical and Translational Science
Chronological age has been the standard for quantifying the aging process. While it is simple to quantify it cannot fully discern the biological variability of aging between individuals. The growing body of interest in this variability of human aging has
Radin Alikhani, Steven R. Horbal, Amy E. Rothberg, Manjunath P. Pai   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Rb-sr ages of chondrules and carbonaceous chondrites [PDF]

Rubidium-strontium and potassium-strontium isotope composition of carbonaceous chondrites and chondrules - age of carbonaceous ...
Compston, W., Murthy, V. R.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Stratigraphy, composition and age of Cuban rudist-bearing deposits

Revista Mexicana de Ciencias Geológicas, 2019
Along the NE flank of Cuba, parts the Bahamian carbonate platform are exposed, while in the central part of the island a Cretaceous volcanic arc sequence is present.
Reinaldo Rojas, Manuel Iturralde-Vicent, Peter W. Skelton   +2 more
doaj