Results 141 to 150 of about 13,772,771 (329)

Predicting Sleep Quality Based on Metabolic, Body Composition, and Physical Fitness Variables in Aged People: Exploratory Analysis with a Conventional Machine Learning Model

Journal of Functional Morphology and Kinesiology
Background: Sleep plays a crucial role in the health of older adults, and its quality is influenced by multiple physiological and functional factors. However, the relationship between sleep quality and physical fitness, body composition, and metabolic ...
Pedro Forte, Samuel G. Encarnação, José E. Teixeira, Luís Branquinho, Tiago M. Barbosa, António M. Monteiro, Daniel Pecos-Martín   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

For Whom the 'Retirement' Bell Tolls: Inter-temporal Comparisons Using the 1994 and 2002 Canadian General Social Survey [PDF]

Data from the 2002 and 1994 General Social Survey are used to analyze the determinants of retiring due to mandatory retirement and the expected age of retirement in Canada.
admin, clsrn, Gomez, Rafael, Gunderson, Morley   +2 more
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Ecology and conservation of bryophytes and lichens on Fagus sylvatica [PDF]

, 2009
Environmental factors related to the occurrence of epiphytic bryophytes and lichens were examined in beech (Fagus sylvatica) forests in the Province of Halland, Sweden.
Fritz, Örjan
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Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Parameterizing probabilities for estimating age-composition distributions for mixture models [PDF]

, 2006
When estimating parameters that constitute a discrete probability distribution {pj}, it is difficult to determine how constraints should be made to guarantee that the estimated parameters { pˆj} constitute a probability distribution (i.e., pˆj>0, Σ pˆj ...
Dorn, Martin W., Kimura, Daniel K.
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Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer

Scientific Reports
Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory response (SIR). Age and SMI/SMD has not been widely studied.
Allan M. Golder, Michael Ferguson, Paul McMillan, David Mansouri, Paul G. Horgan, Campbell S. Roxburgh, Ross D. Dolan, Josh McGovern, Donald C. McMillan   +8 more
doaj   +1 more source

Recent trends in U.S. male work and wage patterns: An overview [PDF]

This paper brings together figures on recent trends in the labor market activity and wages of working-age men in the United States over the 1967-1992 period.
L. Buron, O. O'Donnell, R. Haveman
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