Results 71 to 80 of about 2,694,408 (308)
Life lived and left: Carey’s equality [PDF]
In a stationary population, age composition and the distribution of remaining lifespans are identical. This equivalence can be used to estimate age structure if information is available on time to death.age composition, age estimation, remaining ...
James W. Vaupel
core
Parameterizing probabilities for estimating age-composition distributions for mixture models [PDF]
, 2006 When estimating parameters that constitute a discrete probability distribution {pj}, it is difficult to determine how constraints should be made to guarantee that the estimated parameters { pˆj} constitute a probability distribution (i.e., pˆj>0, Σ pˆj ...
Dorn, Martin W., Kimura, Daniel K.
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Sample composition alters associations between age and brain structure
Nature Communications, 2017 The influence of sample composition on human neuroimaging results is unknown. Here, the authors weight a large, community-based sample to better reflect the US population and describe how applying these sample weights changes conclusions about age ...
Kaja Z. LeWinn +4 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Body Posture Defects and Body Composition in School-Age Children
Children, 2020 The aim of the study was to assess the relationship between the shape of the anteriorposterior spinal curvature and body composition in schoolchildren. The study included 257 children, aged 11–12.
Jacek Wilczyński +2 more
doaj +1 more source
Nitrate leaching in grazed grasslands of different composition and age [PDF]
, 2002 In a field experiment at Research Centre Foulum a suction cup technique was used to investigate nitrate leaching from grassland depending on composition (grass-clover or perennial ryegrass), management (grazing or cutting) and age of the swards.
Eriksen, J., Vinther, F.P.
core
Effect of timing and female quality on clutch size in the Collared Flycatcher Ficedula albicollis [PDF]
, 2004 Capsule: Laying date and female age appear to be related to clutch size. Aims: To test two hypotheses ('date' and 'quality'), which might explain why fewer eggs are laid late in the season.
Garamszegi, László Zsolt +2 more
core +1 more source