Results 91 to 100 of about 1,997,641 (297)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mass and luminosity evolution of young stellar objects

, 2012
A model of protostar mass and luminosity evolution in clusters gives new estimates of cluster age, protostar birthrate, accretion rate and mean accretion time.
Allen, Allen, Bally, Baraffe, Beerer, Bonnell, Bressert, Briceño, Burkert, Cunningham, Da Rio, De Marchi, Dunham, Dunham, Enoch, Enoch, Evans, Gorlova, Gutermuth, Gutermuth, Harvey, Harvey, Hosokawa, Huff, Huff, Jørgensen, Kirk, Koenig, Krumholz, Kryukova, Lee, Li, Luhman, Luhman, Luhman, Masiunas, McKee, McKee, Muench, Myers, Myers, Myers, Myers, Myers, Nakamura, Offner, Offner, Palla, Peterson, Philip C. Myers, Pudritz, Ridge, Tan, Teixeira, Terebey, Wang, Winston, Winston, Wolk   +58 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Statistical methods for estimating tephra source and dispersal : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Statistics at Massey University, Palmerston North, New Zealand [PDF]

, 2016
Tephra refers to any pyroclastic fragments ejected from a volcanic vent and its dispersal is one of the major hazards with explosive eruptions. The attenuation of tephra fall thickness is most commonly estimated after contouring field measurements into
Kawabata, Emily
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The supernova remnant CTB 37B and its associated magnetar CXOU J171405.7-381031: evidence for a magnetar-driven remnant

, 2011
We discuss in this Letter the association of the candidate magnetar CXOU J171405.7-381031 with the supernova remnant CTB 37B. The recent detection of the period derivative of the object allowed an estimation of a young characteristic age of only $\sim ...
Allen, Ankay, Burrows, Caswell, Clark, Davies, Figer, Gaensler, Gaensler, Halpern, Halpern, Hamuy, Horvath, J. E Horvath, M. P Allen, Marsden, Moiseenko, Muno, Sato, Thompson, Truelove, Woosley, Yu   +22 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Nonparametric Calibration for Age Estimation

Journal of the Royal Statistical Society Series C: Applied Statistics, 2002
SUMMARY A method is proposed for the calibration of a continuous random variable when the dependent variables are a combination of continuous and categorical, and the model between the controlling variables and calibrated variable is empirically derived.
Lucy, David, Ackroyd, R. G., Pollard, M.
openaire   +1 more source

Bayesian Analysis of Hazard Regression Models under Order Restrictions on Covariate Effects and Ageing [PDF]

We propose Bayesian inference in hazard regression models where the baseline hazard is unknown, covariate effects are possibly age-varying (non-proportional), and there is multiplicative frailty with arbitrary distribution.
Bhattacharjee, Arnab, Bhattacharjee, Madhuchhanda   +1 more
core   +1 more source