Results 161 to 170 of about 9,169,898 (343)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Assessment of the comorbidity index in patients with ischemic heart disease before coronary artery bypass treatment

open access: yesPatologìâ
The aim of the work: to determine the prevalence and establish the frequency of comorbidity in patients with ischemic heart disease when planning myocardial revascularization by performing coronary artery bypass grafting. Materials and methods.
O. O. Zhurba   +2 more
doaj   +1 more source

Late Antenatal Care Booking And Its Predictors Among Pregnant Women In South Western Nigeria [PDF]

open access: yes, 2008
Introduction: Antenatal care is concerned mainly with prevention, early diagnosis and treatment of general medical and pregnancy associated disorders. For it to be meaningful, early booking is recommended, however, late booking is still a major problem ...
Adekanle, DA, Isawumi, AI
core  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Tabagismo em adolescentes de área urbana na região Sul do Brasil

open access: yesRevista de Saúde Pública
OBJETIVO: Descrever a prevalência e os fatores de risco para o tabagismo em uma amostra de base populacional de adolescentes residentes em área urbana.
Bernardo Lessa Horta   +4 more
doaj  

Standards of rider comfort: Noise, vibration and age of rider as factors [PDF]

open access: yes
Psychological responses of bus passengers to noise and vibration in terms of ride quality are studied in a field test.
Colegate, R. L.
core   +1 more source

Marrying Out: One-in-Seven New U.S. Marriages Is Interracial or Interethnic [PDF]

open access: yes, 2010
Examines trends in and attitudes toward marriages between different races/ethnicities since 1980, including rates of intermarriage by race/ethnicity, gender, region, education, and age.
Jeffrey S. Passel   +2 more
core  

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

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