Results 41 to 50 of about 9,298,387 (344)

Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Scientific Reports
Tau proteins as neurofibrillary tangles are one of the molecular hallmarks of Alzheimer’s disease (AD) and play a central role in tauopathies, a group of age-related neurodegenerative disorders.
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocca   +5 more
doaj   +1 more source

Human Factors in Information-Age Trade Secret Protection [PDF]

, 2011
[Excerpt] Trade secret information security involves a multi-dimensional array of human, legal, and technological factors. I argue that organizational culture, employee policies, and other human factors are fundamental prerequisites to the successful ...
Elbaum, Dan
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gap in the Intensity of End-of-Life Care between Younger and Older Taiwanese Adult Cancer Patients may not Reflect Younger Patients’ Preferences

Journal of Cancer Research and Practice, 2015
Background: Studies on age-related differences in preferences for end-of-life (EOL) care have generally concluded that increasing age predisposes patients to prefer less aggressive EOL care. However, these studies seldom are adjusted for healthcare needs,
Siew-Tzuh Tang, Tsang-Wu Liu, Jyh-Ming Chow, Chang-Fang Chiu, Chiun Hsu, Li-Ni Liu, Su-Ching Kuo   +6 more
doaj   +1 more source

The menopausal age and associated factors in Gorgan, Iran [PDF]

, 2013
Background: Considering the physical, emotional and psychological complications of early or delayed menopause on women's life, it is necessary to determine associated factors of menopause age.
Abdollahi, A.A., Ansari, A., Asayesh, H., Mansourian, M., Noroozi, M., Qorbani, M., Rezapour, A., Soleimani, M.A.   +7 more
core  

Patient acceptability, safety and access : A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations [PDF]

, 2018
© 2017 Elsevier B.V. All rights reserved.The selection and design of age-appropriate formulations intended for use in paediatric and geriatric patients are dependent on multiple factors affecting patient acceptability, safety and access.
Ernest, Terry B., Liu, Fang, Ranmal, Sejal R., Walsh, Jennifer   +3 more
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

A case-control study of drug risk factors for age-related macular degeneration.

, 2007
OBJECTIVE: To investigate the association between age-related macular degeneration (AMD) and exposure to antacids, antithyroids, thyroid hormones, and thiazide diuretics. DESIGN: Matched case-control study.
Chakravarthy, Usha, Cook, Claire, Douglas, Ian J, Fletcher, Astrid E, Hubbard, Richard, Smeeth, Liam   +5 more
core   +1 more source

Nutritional factors and immunological ageing [PDF]

Proceedings of the Nutrition Society, 2006
Undernutrition profoundly affects immune responses, particularly at the extremities of life: in infants and in the elderly. The present review focuses on this interrelationship in the elderly. It describes three different stages of ageing: stage 1, healthy ageing, which is observed in very healthy elderly individuals who have no nutritional deficit ...
openaire   +2 more sources

Forkhead transcription factors and ageing [PDF]

Oncogene, 2008
Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory model organisms. Some of the mechanisms involved show evolutionary conservation, opening the way to using simpler invertebrates to understand human ageing.
L, Partridge, J C, Brüning
openaire   +2 more sources