Results 71 to 80 of about 4,228,950 (269)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The relationship between BRCA-associated breast cancer and age factors: an analysis of the Japanese HBOC consortium database. [PDF]

J Hum Genet, 2021
Okano M, Nomizu T, Tachibana K, Nagatsuka M, Matsuzaki M, Katagata N, Ohtake T, Yokoyama S, Arai M, Nakamura S.   +9 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prevalence of Self-reported Polycystic Ovary Syndrome and Profiles of Health Among Women of Different Generations: A Cross Sectional Study

Fertility & Reproduction, 2019
Objective: Although polycystic ovary syndrome (PCOS) is considered a lifelong disorder, very little is understood about the diagnosis and impact of this condition in women outside of the peak reproductive years.
Jodie C. Avery, Lisa J. Moran, Vivienne Moore, Renae C. Fernandez, Melissa Whitrow, Nigel Stocks, Tiffany K. Gill, Michael Musker, Michael Davies, Alice Rumbold   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Some aspects of circular depressive disorders pathomorphosis at present

Zaporožskij Medicinskij Žurnal, 2017
The article analyzes features of circular depressive disorders socio-demographic and clinical pathomorphosis in period of 1971 to 2016. The aim of the work was to study the features of circular depressive disorders pathomorphosis at present ...
N. G. Pshuk , I. S. Pototska, О. О. Belov   +2 more
doaj   +1 more source

A Geriatric Patient: Age Is Not a Factor

International Journal of Dentistry, 2011
Objective.A patient presented to the dental office expressing dissatisfaction with the appearance of his teeth, and as a result, of his smile. Our objective was to satisfy his initial chief complaint: “I don't like how my teeth look when I smile.”Methodology.Upon completing all initial exams and consultations, an esthetic dental treatment plan was ...
Lisa Klodnitskaya, Michele M. Harutunian, Santiago Mareque Buenos, Denise Estafan, Mark S. Wolff   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gender, age and cultural characteristics of professional resilience in psychologists working in Ukraine's security and defence sector

Гуманітарні студії: педагогіка, психологія, філософія
This article provided a comprehensive analysis of the gender, age and cultural factors that determined professional resilience in psychologists working in Ukraine's security and defence sector (SDS).
V. Koss
doaj   +1 more source