Results 111 to 120 of about 6,185,159 (310)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Factors of Work Motivation in Production Engineering for Baby Boomers, Generations X, Y and Z

open access: yesManagement Systems in Production Engineering
The aim of this study is to identify and evaluate the specific characteristics, preferences, and needs of different generations in the workplace to support management that is more effective, motivation, and employee retention.
Maříková Monika   +3 more
doaj   +1 more source

ON SOME ASPECTS OF THE MANAGEMENT OF A STOCHASTICALLY DEVELOPING FOREST [PDF]

open access: yes
In this paper I focus on some important biological aspects of the forest management problem. I model a stochastically developing forest as a multidimensional, continuous-time Markov chain.
Batabyal, Amitrajeet A.
core   +1 more source

Incidence of Corrective Procedures After Nonoperatively Managed Distal Radius Fractures in the Elderly. [PDF]

open access: yes, 2019
Although the majority distal radius fractures in the elderly are initially managed nonoperatively, the true incidence of subsequent corrective surgery is unknown.
Immerman, Igor   +3 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Age management practices toward workers aged 45 years or older: an integrative literature review. [PDF]

open access: yesRev Bras Med Trab, 2020
Pedro DRC   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Review of Varicella zoster virus : from epidemiology to prevention [PDF]

open access: yes, 2008
The Varicella zoster virus is a human pathogen which causes Varicella after primary infection and herpes zoster after secondary reactivation. Both disease manifestations can occur at any age; however, Varicella is seen more commonly in children whilst ...
Pace, David
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Economics of Copyright Collecting Societies and Digital Rights: Is There a Case for a Centralised Digital Copyright Exchange? [PDF]

open access: yes, 2012
Copyright collecting societies have attracted economists’ attention for over 30 years and the attention of government regulators for even longer. They have typically been accepted by economists and by courts of law as necessary for reducing transaction ...
Towse, Ruth
core  

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