Results 61 to 70 of about 1,594,214 (312)

Early onset of cannabis use and violent behavior in psychosis [PDF]

, 2020
BACKGROUND: Although evidence from psychosis patients demonstrates the adverse effects of cannabis use (CU) at a young age and that the rate of CU is high in subgroups of young violent patients with psychotic disorders, little is known about the possible
Conus, P, Alameda, Luis, Gasser, Jacques, Baumann, PS, Baumann, Philipp, Gholam-Rezaee, Mehdi, Alameda, L, Framorando, D, Baumann, Philipp-S., Do Cuenod, Kim-Q., Cuenod, Kim-Q Do, Moulin, V, Gholam, M, Do Cuenod, KQ, Gasser, J, Gholam, Mehdi, Moulin, Valerie, Framorando, David, Conus, Philippe   +18 more
core   +1 more source

No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders Extra, 2012
Background/Aims: PiggyBac transposable element derived 1 (PGBD1) encodes a molecule involved in epigenetic mechanisms that have been implicated in Alzheimer’s disease (AD), and recent genome-wide association studies and meta-analyses have indicated that ...
Tohru Ohnuma, Tohru Nakamura, Yuto Takebayashi, Ryo Hanzawa, Maiko Kitazawa, Ryoko Higashiyama, Mayu Takeda, Katrin Thompson, Miwa Komatsu, Hiromi Shimazaki, Nobuto Shibata, Heii Arai   +11 more
doaj   +1 more source

OSA-Onset: An algorithm for predicting the age of OSA onset

Sleep Medicine, 2023
There is currently no way to estimate the period of time a person has had obstructive sleep apnoea (OSA). Such information would allow identification of people who have had an extended exposure period and are therefore at greater risk of other medical disorders; and enable consideration of disease chronicity in the study of OSA pathogenesis/treatment ...
Michelle Olaithe, Erica W. Hagen, Jodi H. Barnet, Peter R. Eastwood, Romola S. Bucks   +4 more
openaire   +2 more sources

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Early‐onset Alzheimer's disease (AD) is highly heritable, yet only 10% of cases are associated with known pathogenic mutations. For early‐onset AD patients without an identified autosomal dominant cause, we hypothesized that their early‐onset disease ...
William G. Mantyh, J. Nicholas Cochran, Jared W. Taylor, Iris J. Broce, Ethan G. Geier, Luke W. Bonham, Ashlyn G. Anderson, Daniel W. Sirkis, Renaud La Joie, Leonardo Iaccarino, Kiran Chaudhary, Lauren Edwards, Amelia Strom, Harli Grant, Isabel E. Allen, Zachary A. Miller, Marilu L. Gorno‐Tempini, Joel H. Kramer, Bruce L. Miller, Rahul S. Desikan, Gil D. Rabinovici, Jennifer S. Yokoyama   +21 more
doaj   +1 more source

Correlation Between Genotype and Age of Onset in Leukoencephalopathy With Vanishing White Matter

Frontiers in Genetics, 2021
Purpose: Leukoencephalopathy with vanishing white matter (VWM) is an autosomal recessive leukoencephalopathy caused by mutations in any of the five genes encoding the subunits of eukaryotic translation initiation factor 2B (eIF2B).
Jiong Deng, Ling Zhou, Jie Zhang, Xuting Chang, Yuwu Jiang, Jingmin Wang, Ye Wu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Factors associated with psychiatric and physical comorbidities in bipolar disorder: a nationwide multicenter cross-sectional observational study

Frontiers in Psychiatry, 2023
BackgroundBipolar disorder (BD) is a chronic and disabling affective disorder with significant morbidity and mortality. Despite the high rate of psychiatric and physical health comorbidity, little is known about the complex interrelationships between ...
Jozef Dragasek, Michal Minar, Peter Valkovic, Peter Valkovic, Maria Pallayova, Maria Pallayova   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Average Age of Menopause and Its Associated Factors Among Women in Tehran

Bihdād, 2013
Background: Menopause means the permanent cessation of menstruation and lead to the fixed and permanent changes in women and is predisposing factors of chronic diseases.
F. Jafari, N. Zafarghandi, M. Abbasi, Z. Khodashenas   +3 more
doaj