Results 71 to 80 of about 69,152 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Opal ring from Novo Brdo and gemstone rings in the late Middle Ages [PDF]

, 2021
Rings made entirely of one piece of gemstone are a rarity in medieval jewellery. One such ring, made of opal, was discovered during the most recent archaeological excavations in Novo Brdo, in a layer above the floor in a house near the north-eastern ramparts of the lower town, which was formed during the second half of the 14th century. This paper will
Bikić, Vesna M., Miladinović, Zoran Ž
openaire  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analysis of the 90º and 150º angles for increment counting in otoliths of estuarine catfish

Ocean and Coastal Research
Fish age can be estimated with the use of age rings in calcified structures, such as otoliths. However, it is important to select an appropriate axis for counting the number of increments and to confirm that the age rings are visible in the otolith and ...
Igor Souza de Morais, Juliana de Souza Azevedo   +1 more
doaj   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Explorative analysis on red mullet (Mullus barbatus) ageing data variability in the Mediterranean

Scientia Marina, 2019
The uncertainty in age estimation by otolith reading may be at the root of the large variability in red mullet (Mullus barbatus) growth models in the Mediterranean.
Pierluigi Carbonara, Walter Zupa, Aikaterini Anastasopoulou, Andrea Bellodi, Isabella Bitetto, Charis Charilaou, Archontia Chatzispyrou, Romain Elleboode, Antonio Esteban, Maria Cristina Follesa, Igor Isajlovic, Angélique Jadaud, Cristina García-Ruiz, Amalia Giannakaki, Beatriz Guijarro, Sotiris Elias Kiparissis, Alessandro Ligas, Kelig Mahé, Andrea Massaro, Damir Medvesek, Chryssi Mytilineou, Francesc Ordines, Paola Pesci, Cristina Porcu, Panagiota Peristeraki, Ioannis Thasitis, Pedro Torres, Maria Teresa Spedicato, Angelo Tursi, Letizia Sion   +29 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source