Results 241 to 250 of about 3,504,476 (344)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The Role of Astrocyte-Neuron Interactions in Shaping Neuronal Maturation during Human Brain Development. [PDF]

Comput Struct Biotechnol J
Zhao M, Zhu Y.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Prognostic Significance of <i>NOTCH3</i> Small Vessel Disease Staging for the <i>NOTCH3</i> p.R544C Variant. [PDF]

Neurol Genet
Shen YC, Chen CH, Chen HC, Cheng YW, Chang CY, Kuo PH, Chen YM, Lee WJ, Tang SC.   +8 more
europepmc   +1 more source

The Ages and Stages of History

, 2022
openaire   +1 more source

A method to establish the relationship between chronological age and stage of union from radiographic assessment of epiphyseal fusion at the knee: an Irish population study

, 2008
Jean E. O’Connor, C Bogue, Liam D. Spence, Jason Last   +3 more
openalex   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study. [PDF]

J Clin Hypertens (Greenwich)
Zhu H, Lui H, He L, Zhang J, Jin Z.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study. [PDF]

Int J Oral Sci
Schmidt-Lauber C, Ebinghaus M, Borof K, Lieske B, Klopp A, Thompson C, Wees L, Dawood Z, Heydecke G, Beikler T, Huber TB, Aarabi G.   +11 more
europepmc   +1 more source