Results 151 to 160 of about 2,462,697 (323)
What matters to people aged 80 and over regarding ambulatory care? A systematic review and meta-synthesis of qualitative studies. [PDF]
Eur J Ageing, 2022 Herrler A, Kukla H, Vennedey V, Stock S.
europepmc +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Revista Facultad Nacional de Salud Pública, 2019 Improving Katz index interpretability contributes to a better understanding of its results facilitating decision making and intervention planning. Objective: To evaluate the validity of the Katz geriatric scale in senior citizens from a Rasch model ...
Diego Fernando Rojas-Gualdrón +4 more
doaj +1 more source
Association of physical fitness with quality of life in community-dwelling older adults aged 80 and over in Poland: a cross-sectional study. [PDF]
BMC Geriatr, 2021 Lepsy E +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Do Consultation Charges Deter General Practitioner Use Among Older People? A Natural Experiment. ESRI WP194. May 2007 [PDF]
, 2007 Background: A change in the pricing of general practitioner care in the Republic of Ireland in 2001 provides a natural experiment of the influence of economic incentives on GP visiting.
Layte, Richard +2 more
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Adaptive Behaviours and Occupancy Patterns in UK Primary Schools: Impacts on Comfort and Indoor Quality [PDF]
, 2018 To improve the quality of school environment and reach state of comfort, it's important that teachers and students take appropriate personal and environmental adaptive behaviours. Studies on adaptive behaviours are mainly focused on adults, especially in
Korsavi, Sepideh Sadat +1 more
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