Results 151 to 160 of about 1,421,492 (241)

Ohio Home for Aged and Infirm Deaf kitchen

, 1951
Photograph showing the kitchen at the Ohio Home for Aged and Infirm Deaf, in Westerville, Ohio, ca. 1953. The Ohio School for the Deaf held its first annual reunion in 1870, and at this time, the OSD Alumni Association decided to build a home for the ...

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SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Providing and financing aged care in Australia

, 2011
Henry Ergas1,2, Francesco Paolucci31University of Wollongong, Wollongong, NSW, Australia; 2Deloitte Australia, Brindabella Business Park, Canberra Airport, ACT, Australia; 3Australian Centre for Economic Research on Health, The Australian National ...
Paolucci F, Ergas H
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Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Family Caregivers of Adults Aged 80 and over: Caregiving as a Stress Process and a Disruption of Occupational Balance. [PDF]

Healthcare (Basel)
Blin A, Bonin-Guillaume S, Arlotto S, Gentile S.   +3 more
europepmc   +1 more source

Aid to the elderly person aged 80 and over in the emergency service: perspective of professionals from nursing homes

Introduction: The increase in the average life expectancy of the population has been significantly reflected in the accentuated rate of aging and the increase in the prevalence of chronic diseases, leading to an increase in the number of people aged 80 ...
Esteves, Madalena, Pina, Fernando, Vicente, João, Ribeiro, Olivério, Cunha, Madalena, Cardoso, Joana   +5 more
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Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Association between serum albumin and preoperative Deep Vein Thrombosis in patients aged 80 and over with intertrochanteric fracture: A retrospective observational study. [PDF]

PLoS One
Chen C, Zhang X.
europepmc   +1 more source