Results 71 to 80 of about 2,462,697 (323)

Central nervous system relapse in patients over 80 years with diffuse large B‐cell lymphoma: an analysis of two LYSA studies

Cancer Medicine, 2018
CNS relapse is reported in 2–5% of diffuse large B‐cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to ...
Aurélie Cabannes‐Hamy, Frederic Peyrade, Fabrice Jardin, Jean‐François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean‐Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont, the LYSA, the lymphoma study association   +22 more
doaj   +1 more source

Safety of Percutaneous Endoscopic Gastrostomy Tubes in Centenarian Patients [PDF]

Clinical Endoscopy, 2018
Background/Aims Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, no study has evaluated the safety of PEG tube placement in patients over the age of 100 years.
Zain A Sobani, Kevin Tin, Steven Guttmann, Anna A Abbasi, Ira Mayer, Yuriy Tsirlin   +5 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice [PDF]

, 2014
BACKGROUND:Mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO) exhibit a complete block in chylomicron assembly together with lipid malabsorption.
Breed, Elise R, Burd, Eileen M, Coopersmith, Craig M, Davidson, Nicholas O, Dominguez, Jessica A, Farris, Alton B, Liang, Zhe, Xie, Yan, Yoseph, Benyam P   +8 more
core   +3 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Are GPs under-investigating older patients presenting with symptoms of ovarian cancer? Observational study using General Practice Research Database [PDF]

, 2010
Background: Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts.
A Majeed, A Moran, A Nicholson, A Quaglia, A R Tate, AL Hansell, C Bouchardy, C Falandry, F Berrino, J A Cassell, J Adams, J De Rijke, JMJ Kirwan, K Haynes, M Peake, N Turner, R Jones, R Neal, R Robertson, SW Pascoe, VL Allgar, W Hamilton   +21 more
core   +3 more sources

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

BMC Geriatrics, 2021
Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and ...
Miguel Germán Borda, Luis Carlos Venegas-Sanabria, Elkin Garcia-Cifuentes, Ronald Camilo Gomez, Carlos Alberto Cano-Gutierrez, Diego Alejandro Tovar-Rios, Vera Aarsland, Khadija Khalifa, Alberto Jaramillo-Jimenez, Dag Aarsland, Hogne Soennesyn   +10 more
doaj   +1 more source

Breast cancer treatment in women over the age of 80: A tailored approach [PDF]

Maturitas, 2018
Breast cancer treatment in women over the age of 80 remains a complex issue due to pre-existing comorbidities, therapy-related toxicities, and the lack of evidence-based data in this population, leading to both overtreatment and under treatment. The average life expectancy of an 80-year-old woman is 9.7 years and chronologic age alone should not be a ...
Rebecca L. Glaser, Constantine Dimitrakakis, Spyridon S Marinopoulos   +2 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

PENGARUH WAKTU PENGENALAN PERTAMA SUSU FORMULA TERHADAP KEJADIAN GIZI LEBIH PADA BAYI USIA 11 - 12 BULAN [PDF]

, 2004
Pengenalan susu formula kepada bayi merupakan masalah yang saat ini mulai banyak timbul di Indonesia. Memberikan susu formula kepada bayi dianggap lebih bergengsi dan lebih praktis dari pada memberikan ASI kepada bayi. Kandungan zat gizi susu formula dan
NUGRAHANINGSIH, PRAMA
core