Results 91 to 100 of about 4,273,508 (315)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Strengthening care for adults with palliative care needs in high-income rural communities: a global policy environmental scan

BMC Palliative Care
Background Almost 45% of the world’s population resides in rural locations. Despite this, access to best evidence-based palliative care is variable. Reforming and optimising rural palliative care is dependent upon positive public policy.
Claire Marshall, Claudia Virdun, Jane L. Phillips   +2 more
doaj   +1 more source

Advanced Maternal Age and the Risk of Low Birth Weight and Preterm Delivery: a Within-Family Analysis Using Finnish Population Registers [PDF]

, 2017
Alice Goisis, Hanna Remes, Kieron Barclay, Pekka Martikainen, Mikko Myrskylä   +4 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Aging, Frailty, and the Microbiome—How Dysbiosis Influences Human Aging and Disease

, 2020
John P. Haran, Beth A. McCormick
openalex   +2 more sources

Systemic clearance of p16^INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration [PDF]

, 2019
Prashanti Patil, Qing Dong, Dong Wang, Jianhui Chang, Christopher D. Wiley, Marco Demaria, Joon Lee, James D. Kang, Laura J. Niedernhofer, Paul D. Robbins, Gwendolyn Sowa, Judith Campisi, Daohong Zhou, Nam Vo   +13 more
openalex   +1 more source

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss [PDF]

, 2020
Oyundari Amartuvshin, Chi‐Hung Lin, Shao‐Chun Hsu, Shih‐Han Kao, Alvin Chen, Wei‐Chun Tang, Hsin-Hung Chou, Dong‐Lin Chang, Yen‐Yang Hsu, Bai‐Shiou Hsiao, Elham Rastegari, Kun‐Yang Lin, Yuting Wang, Chi‐Kuang Yao, Guang‐Chao Chen, Bi‐Chang Chen, Hwei‐Jan Hsu   +16 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Ageing [PDF]

Nature, 2010
openaire   +2 more sources

Slowing Down: Age-Related Neurobiological Predictors of Processing Speed [PDF]

, 2011
Mark A. Eckert
openalex   +1 more source