Results 111 to 120 of about 4,273,508 (315)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment [PDF]

, 2019
Ellen Quarles, Nathan Basisty, Ying Ann Chiao, Gennifer E. Merrihew, Haiwei Gu, Mariya T. Sweetwyne, Jeanne Fredrickson, Ngoc‐Han Nguyen, Maria V. Razumova, Kristina B. Kooiker, Farid Moussavi‐Harami, Michael Regnier, Christopher L. Quarles, Michael J. MacCoss, Peter S. Rabinovitch   +14 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Aloe vera or Resveratrol Supplementation in Larval Diet Delays Adult Aging in the Fruit Fly, Drosophila melanogaster [PDF]

, 2011
K. T. Chandrashekara, Mallikarjun Shakarad   +1 more
openalex   +1 more source

Temporal Trends in Dietary Sodium Intake Among Adults Aged ≥19 Years — United States, 2003–2016 [PDF]

, 2021
Lasha Clarke, Katherine J. Overwyk, Marlana Bates, So-Youn Park, Cathleen Gillespie, Mary E. Cogswell   +5 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Aging

Experimental Animals, 2020
openaire   +3 more sources

Perturbative quantum gravity comes of age [PDF]

, 2014
R. P. Woodard
openalex   +1 more source

Photochemical Aging Induces Changes in the Effective Densities, Morphologies, and Optical Properties of Combustion Aerosol Particles [PDF]

, 2023
Jani Leskinen, Anni Hartikainen, Sampsa Väätäinen, Mika Ihalainen, Aki Virkkula, Arūnas Meščeriakovas, Petri Tiitta, Mirella Miettinen, Heikki Lamberg, Hendryk Czech, Pasi Yli‐Pirilä, Jarkko Tissari, Gert Jakobi, Ralf Zimmermann, Olli Sippula   +14 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source