Results 201 to 210 of about 7,426,653 (346)

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Sequence Skill Acquisition and Off-Line Learning in Normal Aging

, 2009
R. Michael Brown, Edwin M. Robertson, Daniel Z. Press   +2 more
openalex   +2 more sources

Inter-individual and age-dependent variability in simulated electric fields induced by conventional transcranial electrical stimulation

, 2020
Daria Antonenko, Ulrike Grittner, Guilherme B. Saturnino, Till Nierhaus, Axel Thielscher, Agnes Flöel   +5 more
openalex   +1 more source

Concise Review: Drug Discovery in the Age of the Induced Pluripotent Stem Cell [PDF]

, 2014
Huaising C. Ko, Bruce D. Gelb
openalex   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation. [PDF]

PLoS Biol
Guo X, Du G, Zhou J, Fu F, Yuan Y, Liu X, Chen H, Wan Q, Gong B, Chen H.   +9 more
europepmc   +1 more source

Effectiveness of 23-Valent Polysaccharide Pneumococcal Vaccine and Changes in Invasive Pneumococcal Disease Incidence from 2000 to 2017 in Those Aged 65 and Over in England and Wales

, 2018
Abdelmajid Djennad, Mary Ramsay, Richard Pebody, Norman K. Fry, Carmen Sheppard, Shamez Ladhani, Nick Andrews   +6 more
openalex   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Quantitative Evaluation of the Blending Between Virgin and Aged Aggregates in Hot-Mix Recycled Asphalt Mixtures. [PDF]

Materials (Basel)
Zou H, Sui Y, Lu W, Wang T, Guo D, Sun X, Liu Z.   +6 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source