Results 221 to 230 of about 4,273,508 (315)

Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity. [PDF]

PLoS Pathog
Kurokawa R, Mtali CS, Daniel IJ, Einarsdottir T, Reda O, Irie N, Sakhor W, Niimura K, Takatori M, Sugata K, Tye CA, Satou Y, Ono M, Nomura T.   +13 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Theoretically Universal, Practically Unequal: Socio-Economic Inequalities in Healthcare Access for Long Covid-19 Patients in Austria. [PDF]

Health Expect
Gamillscheg-Müllner P, Łaszewska A, Diexer S, Hoffmann K, Simon J, Mayer S.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A Retrospective Linked Data Analysis of Acute Rheumatic Fever and Rheumatic Heart Disease Diagnoses in Children Aged Under Five Years in Australia, 2001-2017. [PDF]

Aust J Rural Health
Cransberg J, Katzenellenbogen J, Remenyi B, Francia C, Murray K, Stacey I.   +5 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Risk biomarkers of chronic GVHD in children aged 10 years or younger and children/adults older than 10 years. [PDF]

Blood Adv
Ferreira AC, Dutta D, Rowan CM, Renbarger J, Cooke KR, Carpenter PA, Krance R, Duncan C, Cruz CRY, Jacobsohn D, Bollard CM, Hill E, Paczesny S.   +12 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey. [PDF]

PLoS One
Sulis G, Maredia N, Wolfson C, Basta NE.
europepmc   +1 more source

Ages of Ages

Ages of Ages is for SATB a capella choir. It is inspired by text taken from the medieval Old Hispanic chant, León 8, fol. 273: Et non deficiet ex te vir qui compleat voluntatem meam; and León 8, fol. 88v: Gloria et honor patri et filio et spiritui sancto et nunc and semper et in saecula saeculorum. An English translation is used for this piece.
openaire   +1 more source