Results 271 to 280 of about 7,426,653 (346)

Estimation of General Practitioner Visits, Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus and Influenza Virus, and Costs Associated With Hospitalizations, in Older Adults in France From 2010 to 2020. [PDF]

Open Forum Infect Dis
Nuttens C, Barbet V, Bignon-Favary C, Lambourg E, Fiévez S, Blanc E, Vacheret M, Liliu H, Vanhems P, Casalegno JS, Watier L, Loubet P, Liang C, Begier E, Lemaitre M.   +14 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling. [PDF]

Nat Commun
Ontiveros CO, Garcia MG, Murray CE, Deng Y, Bai H, Tanner C, Leung B, Li X, Padron A, Reyes RM, Kancharla A, Soh KT, Krishnan S, Chand D, Balasubramanian A, Hegner C, Jakubzick CV, Gupta HB, Turk MJ, Sundrud M, Conejo-Garcia JR, Curiel TJ.   +21 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Correction: BEFRIENding for depression, anxiety and social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol

BMC Geriatrics
Colleen Doyle, Sunil Bhar, Christina Bryant, Briony Dow, David Dunt, George Mnatzaganian, Daniel O’Connor, Julie Ratcliffe, Emily You, Anne-Marie Bagnall, Georgia Major, Robin Harper, Marcia Fearn   +12 more
doaj   +1 more source

Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice. [PDF]

Elife
Donofrio SG, Brandenburg C, Brown AM, Lin T, Lu HC, Sillitoe RV.   +5 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Increased Opioid Exposure in Older Adults During COVID-19: An Interrupted Times Series Analysis. [PDF]

Health Sci Rep
Abraham AJ, Steuart SR, Harris SJ, Bethel V.   +3 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source