Results 101 to 110 of about 2,393,425 (335)

APPLICABILITY OF DIET QUALITY ASSESSMENT INSTRUMENTS IN THE OLDEST-OLD: AMPAL STUDY

Geriatrics, Gerontology and Aging, 2020
OBJECTIVE: To compare the applicability of the 2006 Brazilian Ministry of Health food guide questionnaire Como ter uma alimentação saudável (QGAS — How to have a healthy diet) and the 2013 National Health Survey healthy eating questionnaire (QA-PNS) for ...
Valéria Baccarin Ianiski, Flávia Picoli Gheno, Ângelo José Gonçalves Bós   +2 more
doaj   +1 more source

Quality of life and depression in elderly persons engaged in physical activities [PDF]

Vojnosanitetski Pregled, 2018
Backgroung/Aim. Since the number of elderly persons is gradually increasing worldwide, there is a need to identify the factors that affect the quality of healthy ageing. On the other hand, depression is the most common psychiatric disorder in the elderly
Trajkov Marija, Eminović Fadilj, Radovanović Saša, Dopsaj Milivoj, Pavlović Dragan, Kljajić Dragana   +5 more
doaj   +1 more source

Inception and deprescribing of statins in people aged over 80 years: cohort study [PDF]

Age and Ageing, 2017
statin use over the age of 80 years is weakly evidence-based. This study aimed to estimate rates of statin inception and deprescribing by frailty level in people aged 80 years or older.a cohort of 212,566 participants aged ≥80 years was sampled from the UK Clinical Practice Research Datalink. Statin inception was defined as a first-ever prescription in
Rathi Ravindrarajah, Judith Charlton, Martin Gulliford, Martin Gulliford, Shota Hamada, Stephen H D Jackson   +5 more
openaire   +6 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Incidence of Cardiovascular Disease and Cancer in Advanced Age: Prospective Cohort Study [PDF]

, 2012
Objective: To investigate the influence of increasing age on the incidence and remaining lifetime risk of cardiovascular disease and cancer in a cohort of older men. Design: Prospective cohort study. Setting: United States.
Djoussé, Luc, Driver, Jane A., Gaziano, John Michael, Kurth, Tobias, Logroscino, Giancarlo   +4 more
core   +1 more source

Exploring an informed decision-making framework using in-home sensors: older adults’ perceptions

Journal of Innovation in Health Informatics, 2014
Background Sensor technologies are designed to assist independent living of older adults. However, it is often difficult for older adults to make an informed decision about adopting sensor technologies.Objective To explore Bruce’s framework of informed ...
Jane Chung, Blaine Reeder, Amanda Lazar, Jonathan Joe, George Demiris, Hilaire J. Thompson   +5 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Discovery of a New Supernova Remnant in the Direction of G69.7+1.0 [PDF]

, 2000
We discovered a middle-aged supernova remnant (SNR) in the vicinity of G69.7+1.0 using the ASCA satellite. G69.7+1.0 was identified in the 2.7 GHz survey and classified as a shell-type SNR with a diameter of 16 arcmin.
Miyata, Emi, Tsunemi, Hiroshi, Yoshita, Kumi   +2 more
core   +3 more sources

Physical frailty prediction model for the oldest old

Revista Latino-Americana de Enfermagem, 2018
Objective: to present a physical frailty prediction model for oldest old users of primary health care, according to clinical variables. Method: cross-sectional study with proportional stratified sample of 243 oldest old subjects.
Jacy Aurelia Vieira de Sousa, Maria Helena Lenardt, Clóris Regina Blanski Grden, Luciana Kusomota, Mara Solange Gomes Dellaroza, Susanne Elero Betiolli   +5 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source