Results 101 to 110 of about 2,584,660 (392)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Road safety education for older drivers : evaluation of a classroom-based training initiative [PDF]

, 2017
Around the world, a growing proportion of drivers are aged 70 or over. Although accident rates for older drivers are lower than for young or novice drivers, increased frailty and slowed reactions mean that older drivers are at higher risk of death or ...
Goodwin, Lacey, Hawley, Carol, Smith, Robert A.   +2 more
core   +1 more source

Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer

OncoTargets and Therapy, 2015
Purpose The aim of this study was to compare single-agent chemotherapy with targeted therapy in initial treatment and to explore a better choice of treatment for patients aged 80 years and older with advanced non-small-cell lung cancer (NSCLC).
Qianqian Zhang, Zhehai Wang, Jun Guo, Liyan Liu, Xiao Han, Minmin Li, S. Fang, X. Bi, N. Tang, Yang Liu   +9 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Findings in young adults at colonoscopy from a hospital service database audit [PDF]

, 2017
Background: Colorectal cancer (CRC) diagnosed at
Drew, P, Hardingham, JE, Hewett, P, Lidums, I, Marker, J, Parry, S, Patel, D, Price, TJ, Roder, D, Rosty, C, Ruszkiewicz, A, Smith, E, Symonds, E, Tomita, Y, Townsend, A, Uylaki, W, Vatandoust, S, Win, AK, Wong, S, Worthley, DL, Young, GP, Young, JP   +21 more
core   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Feasibility study of early outpatient review and early cardiac rehabilitation after cardiac surgery: mixed-methods research design-a study protocol. [PDF]

, 2019
INTRODUCTION: Following cardiac surgery, patients currently attend an outpatient review 6 weeks after hospital discharge, where recovery is assessed and suitability to commence cardiac rehabilitation (CR) is determined.
Akowuah, Enoch, Dean, Alexandra, Doherty, Patrick Joseph, Fairhurst, Caroline, Flemming, Kate, Hewitt, Catherine, Hinde, Sebastian, Hirst, Claire, Mitchell, Alex, Mitchell, Natasha, Ngaage, Dumbor, Nichols, Simon, Watson, Judith   +12 more
core   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Wealth, income and dementia in Germany: longitudinal findings from a representative survey among the oldest old

BMC Public Health
Background There is limited knowledge on the link between wealth, as well as income, and dementia risk among the oldest old (80 years and over). The purpose of our study was to examine the association between income, wealth, and dementia among the oldest
André Hajek, Hans-Helmut König, Snorri Bjorn Rafnsson, Razak M. Gyasi   +3 more
doaj   +1 more source

Are GPs under-investigating older patients presenting with symptoms of ovarian cancer? Observational study using General Practice Research Database [PDF]

, 2010
Background: Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts.
A Majeed, A Moran, A Nicholson, A Quaglia, A R Tate, AL Hansell, C Bouchardy, C Falandry, F Berrino, J A Cassell, J Adams, J De Rijke, JMJ Kirwan, K Haynes, M Peake, N Turner, R Jones, R Neal, R Robertson, SW Pascoe, VL Allgar, W Hamilton   +21 more
core   +3 more sources