Results 81 to 90 of about 1,248,790 (310)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Diagnosis and management of osteoporosis in the older senior
Clinical Interventions in Aging, 2009 Sheryl F Vondracek, Sunny A LinneburDepartment of Clinical Pharmacy, School of Pharmacy C238-L15, University of Colorado Denver, Aurora, CO, USAAbstract: The older senior is at high risk for osteoporosis.
Sheryl F Vondracek, Sunny A Linnebur
doaj
Exploring an informed decision-making framework using in-home sensors: older adults’ perceptions
Journal of Innovation in Health Informatics, 2014 Background Sensor technologies are designed to assist independent living of older adults. However, it is often difficult for older adults to make an informed decision about adopting sensor technologies.Objective To explore Bruce’s framework of informed ...
Jane Chung +5 more
doaj +1 more source
, 2019 Supplemental material, Baseline_characteristics for No clear relationship between antihypertensive class and cognitive function over 12 months in a cohort study of community-dwelling adults aged 80 and over by Ruth Peters in Therapeutic Advances in ...
Ruth Peters (95923)
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
BMC Public HealthBackground There is limited knowledge on the link between wealth, as well as income, and dementia risk among the oldest old (80 years and over). The purpose of our study was to examine the association between income, wealth, and dementia among the oldest
André Hajek +3 more
doaj +1 more source
BMC Geriatrics, 2019 Background Enhanced recovery programmes (ERPs) aim to attenuate the surgical stress response and accelerate recovery after surgery, but are not specifically designed for older patients.
Katleen Fagard +6 more
doaj +1 more source
, 2014 出版社版Background: The aims of this study are (1) to investigate the occurrence rate of postoperative complications in patients ≥ 80 years old after cardiac surgery and (2) to elucidate the impact of the most common postoperative complications on mortality ...
カミヤ, ヒロユキ +8 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
French normative data for the Complex Rey Figure Test in healthy subjects aged over 80 years
, 2022 International audienceTo our knowledge, there are few studies on the cognitive assessment of very old people, over 80 years old in the French population.
Destrieux, Christophe +4 more
core +1 more source