Results 101 to 110 of about 1,248,790 (310)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quality of life and socio-demographic factors associated with nutritional risk in Brazilian community-dwelling individuals aged 80 and over: cluster analysis and ensemble methods. [PDF]

Front Nutr, 2023
Brech GC, da Silva VC, Alonso AC, Machado-Lima A, da Silva DF, Micillo GP, Bastos MF, de Aquino RC.   +7 more
europepmc   +1 more source

Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over

, 1997
Objectives: To provide a reference range for plasma total homocysteine (tHcy), an independent risk factor for vascular disease, and to explore relationships with nutritional indices for people aged 65 y and over, in the UK National Diet and Nutrition ...
vanderPols, J, Finch, S., Mansoor, MA, Bates, CJ, Prentice, A, Prentice, A., Finch, S, Bates, C. J., Mansoor, M. A., Cole, T. J., Cole, TJ, van der Pols, J.   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cholecystectomy for gallbladder disease in elderly aged 80 years and over.

, 2009
BACKGROUND/AIMS: Patients aged 80 years and over show greater risk of complicated gallbladder diseases and associated comorbidities. The aim of the study is to evaluate the prognosis after laparoscopic or open cholecystectomy in these patients ...
PIETROLETTI, Renato, DE VITA F, SIMI M., LEARDI, Sergio   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Analysis of Outcomes in Pancreaticoduodenectomy for Elderly Patients Aged 80 and Above: A Retrospective Study Using Inverse Probability of Treatment Weighting

Aging Medicine
Objectives With an aging population, more elderly individuals are facing the decision to undergo complex surgeries, such as pancreaticoduodenectomy (PD). This study evaluates the safety and feasibility of PD in patients aged 80 and above.
Tianxiao Wang, Yue Qiu, Yingjixing Luo, Ruili Wei, Li Xu, Jia Huang, Wenying Zhou, Hanchun Huang, Yongliang Sun, Zhiying Yang   +9 more
doaj   +1 more source

Prevalence of household falls in long-lived adults and association with extrinsic factors

Revista Latino-Americana de Enfermagem, 2017
Resume Objective: to identify the prevalence of falls among older adults and the extrinsic factors associated with them. Method: population-based cross-sectional study with 350 older adults.
Silviane Galvan Pereira, Claudia Benedita dos Santos, Marlene Doring, Marilene Rodrigues Portella   +3 more
doaj   +1 more source

COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes-Six Pandemic Waves: OCTA-COVID Study. [PDF]

Int J Environ Res Public Health, 2022
Ruiz-Huerta C, Canto MV, Ruiz C, González I, Lozano-Montoya I, Quezada-Feijoo M, Gómez-Pavón FJ.   +6 more
europepmc   +1 more source

Nursing Home Residents Aged over 80—A Cross-Sectional Analysis on Which Activity Traits Correlate to Positive Affect

, 2020
Admission to a care facility is assumed to enhance depressive symptoms and dependent behavior in old age. In this context, the relevance of participation in activities that make everyday life in a care facility more pleasant has been pointed out.
Melanie Zirves, Holger Pfaff
core   +1 more source