In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
“Is Life Worth Living?”: The Role of Masculinity in the Way Men Aged Over 80 Talk About Living, Dying, and Suicide [PDF]
Kylie King+7 more
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AB0698 SYSTEMIC LUPUS ERYTHEMATOSUS OVER 80 YEARS OF AGE: A RETROSPECTIVE COHORT OF VERY LATE-ONSET IN A THIRD LEVEL HOSPITAL [PDF]
Antía Crespo-Golmar+5 more
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Current trends in single‐cell RNA sequencing applications in diabetes mellitus
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian+6 more
wiley +1 more source
Laparoscopic surgery for colorectal cancer in patients over 80 years of age: the morbidity outcomes [PDF]
Sang Woo Lim+2 more
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Clinical and epidemiological characterization of adults over the age of 80 with acute coronary syndrome [PDF]
Álvaro Rodríguez+7 more
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Earthing effects on mitochondrial function: ATP production and ROS generation
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
18IS THERE A NEED FOR ‘SPECIALISTS’ TO BECOME ‘GENERALISTS’? A SURVEY COMPARING HOSPITAL OUTCOMES IN OLDER PATIENTS AGED OVER 75 YEARS WHO ARE MANAGED BY GENERAL PHYSICIANS VERSUS THOSE AGED OVER 80 YEARS MANAGED BY OLDER PEOPLE'S MEDICINE PHYSICIANS (OPM) [PDF]
G Dawson+3 more
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The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo+4 more
wiley +1 more source