Results 101 to 110 of about 998,871 (360)

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

Acta Neuropathologica Communications, 2019
Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia.
Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge   +5 more
doaj   +1 more source

Decision letter for "Impact of wood species on microbial community composition, beer chemistry and sensory characteristics during barrel‐ageing of beer"

, 2021

openalex   +1 more source

Demographic change and regional competitiveness: The effects of immigration and ageing [PDF]

, 2007
The demographic profile of a region is usually seen as a slowly changing background phenomenon in the analysis of regional competitiveness and regional growth. However, regional demographic change can have a significant impact on regional competitiveness
Poot, Jacques
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Author Correction: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

Nature Communications, 2021
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Sebastian Grönke, Linda Partridge, Adam Antebi   +8 more
doaj   +1 more source

Six weeks of strength endurance training decreases circulating senescence-prone T-lymphocytes in cytomegalovirus seropositive but not seronegative older women

Immunity & Ageing, 2019
Background Ageing is associated with a decline in immune function termed immunosenescence. This process is characterized amongst others by less naive T-cells and more senescent phenotypes, which have been implicated in the pathogenesis of many age ...
Hung Cao Dinh, Ivan Bautmans, Ingo Beyer, Oscar Okwudiri Onyema, Keliane Liberman, Liza De Dobbeleer, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Andreas Delaere, Veerle Knoop, Rose Njemini   +11 more
doaj   +1 more source

Macroeconomic Consequences of Ageing and Directed Technological Change. BertelsmannStiftung Studies [PDF]

, 2019
Macroeconomic Consequences of Ageing and Directed Technological Change Demographic projections foresee a pronounced population ageing process in the coming decades.
Kaniovski, Serguei, Url, Thomas
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Free wall rupture in the elderly: deleterious effect of fibrinolytic therapy on the ageing heartThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology. [PDF]

, 2005
Ellen C. Keeley, James A. de Lemos
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source