Results 291 to 300 of about 929,250 (364)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, Volume 15, Issue 5, Page 726-737, May 2025.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

The Problem of the Ageing Population

, 1963
Julie McMullan
openalex   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, Volume 15, Issue 5, Page 763-772, May 2025.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

A Resistometric Study of the Early Stage of Ageing in Lead-Magnesium Alloy

, 1969
Ryoichi Nozato, H. Tsubakino
openalex   +2 more sources

The Reformation of Age and Ageing [PDF]

Journal of Population Ageing, 2017
openaire   +2 more sources

Corrigendum: Ageing, clinical complexity, and exercise therapy: a multidimensional approach. [PDF]

Front Sports Act Living
Corrao S, Cerasola D, Lucini D, Argano C.   +3 more
europepmc   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, Volume 15, Issue 5, Page 856-866, May 2025.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Theobromine is Associated with Slower Epigenetic Ageing

Saad R, Costeira R, Matias Garcia PR, Gieger C, Suhre K, Peters A, Kastenmüller G, Rodriguez-Mateos A, Dias C, Menni C, Waldenberger M, Bell JT.   +11 more
europepmc   +1 more source

Sex and education differences in trajectories of physiological ageing: longitudinal analysis of a prospective English cohort study. [PDF]

Age Ageing
Bloomberg M, Steptoe A.
europepmc   +1 more source