Results 81 to 90 of about 998,871 (360)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Jockey Club Age-Friendly City Project : Action plan : Tuen Mun

, 2017
In response to the global ageing population, the World Health Organization (the “WHO”) devised the concept of “Global Age-friendly Cities” in 2005 to encourage cities all around the world to develop a healthy and comfortable living environment with age ...
Asia-Pacific Institute of Ageing Studies, Lingnan University
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The role of initial conditions in the ageing of the long-range spherical model

, 2008
The kinetics of the long-range spherical model evolving from various initial states is studied. In particular, the large-time auto-correlation and -response functions are obtained, for classes of long-range correlated initial states, and for magnetized ...
Annibale A, Annibale A, Baumann F, Calabrese P, Calabrese P, Calabrese P, Fedorenko A A, Godrèche C, Joyce G S, Picone A, Sreedhar B Dutta   +10 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

157 THE MANAGEMENT OF URINARY INCONTINENCE IN NURSING HOMES: FINDINGS FROM A SCOPING REVIEW

Continence, 2022
J Ostaszkiewicz, L Kosowicz, J Cecil, E Wise, S Garratt, D Somanader, B Dow   +6 more
doaj   +1 more source

The IMPART (IMproving PAlliative care in Residential aged care using Telehealth) trial: a stepped-wedge cluster-randomised controlled trial protocol

BMC Geriatrics
Background The quality of palliative and end-of-life care (EOLC) in residential aged care (RACFs) is variable, and often suboptimal. The aim of IMPART is to improve palliative care in RACFs.
Anita M. Y. Goh, Katrin Gerber, Kayla Lock, Ellen Gaffy, Kerry Hwang, Anna Lane, Kirsten J. Moore, Barbara Hayes, Lidia Engel, Mark Tacey, Brian Le, Paul Yates, Melissa J. Bloomer, Len Gray, Dimity Constance Pond, Danny Hills, Frances Batchelor, Ross Bicknell, Debra Nestel, Christina Johnson, Steven Savvas, Karen Bodna, Penny Harvey, Aaron B. Wong, Bonnie Lui, Wen Kwang Lim   +25 more
doaj   +1 more source

Coming of age [PDF]

, 2011
Copyright at Demos 2011. This work is made available under the terms of the Demos licence.Britain’s ageing population is often described as a demographic time-bomb.
Bazalgette, L, Holden, J, Hubble, N, Morrison, J, Tew, P   +4 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source