Results 111 to 120 of about 2,209,223 (316)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Environmental Research: Food SystemsA growing body of research highlights the central role that actors play in shaping food system resilience. While individual studies have examined the contributions of specific actors, there remains a lack of synthesis that captures cross-sectoral ...
Jing Zhang, David Tyfield, Lingxuan Liu
doaj +1 more source
Homeless Agency: making it home: annual report: 2004.
, 2005 The Homeless Agency is a partnership body that was established as part of the Government strategy on homelessness in May 200 l. It is responsible for the planning and co-ordination of the delivery of quality services to people who are homeless in ...
Homeless Agency
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Health Services Employers Agency annual report 1998. [PDF]
, 1998 The Health Service Employers Agency (HSEA) was established on 15th July 1996 under Statutory Instrument 5.1. 213/1996, pursuant to the provisions of the Health (Corporate Bodies) Act, 1961.
Health Services Employers Agency (HSEA)
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
"Ought", Agents and Ambiguity that Matters
Studia Semiotyczne, 2019 DOI: http://doi.org/10.26333/sts.xxxi2.06 According to a well-homed view in linguistic semantics, deontic logic and logic of agency, some ‘ought’ sentences, like ‘Kate ought to write the report’, are ambiguous between the socalled agentive sense as ...
Joanna Klimczyk
doaj
Agency Fiscal Report: Fiscal Year 2011
, 2011 A report about USAID which is a government agency that provides economic, developmental, and humanitarian assistance around the world to support foreign countries.
United States. Environmental Protection Agency.
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source