Results 41 to 50 of about 908,495 (266)

Social Management, Acceleration and Capital Logic during the COVID-19 Pandemic: Experiences in the Colombian Context

RHS Revista Humanismo y Sociedad
This work analyzes the role of social management in the context of volatility, uncertainty, complexity and ambiguity, which is typical of the current era, but is, at the same time, a consequence of the prevailing economic model. Likewise, it analyzes the
José Miguel Segura Gutiérrez, Heraldi Torres, Diana Victoria Rodríguez   +2 more
doaj   +1 more source

Iconoclasme, histoire de l’art et valeurs

Perspective, 2018
Recognizing the profusion of studies on the phenomena of destruction, this essay begins by analyzing the historiographical situation of the early 1980s. Ulmer Verein für Kunstwissenschaft responded to the prescriptive perspective of Louis Réau’s Histoire
Dario Gamboni
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

AI as a Design Material: Dealing with new agencies

Temes de Disseny, 2019
As Artificial Intelligence, Machine Learning, Big Data, and other technologies become widespread they could be seen as new materials for design. But what are the special traits of these materials? How should design incorporate them in its practices? How
Ramon Sangüesa, Ariel Guersenzvaig
doaj  

Retour réflexif sur la construction d’un objet géographique mémoriel

Géographie et Cultures, 2015
This paper seeks to revisit and discuss the intellectual construction of the Shoah as a spatial object. We endeavor to hark back to its genesis, to delineate the references and stakes that topic raises in the geographical field as well as to find out ...
Dominique Chevalier
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Rethinking the Role of Free will in Legal Responsibilities in the Light of the Findings of Modern Neuro-pilosophy [PDF]

حقوق فناوریهای نوین
The main purpose of this article is to rethink the effect of free will in choosing a decision and committing legal actions and realizing the resulting responsibility in the light of recent advances and developments in neuroscience and contemporary ...
Smaeil keshavarz
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source