Results 71 to 80 of about 5,082,581 (316)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Asserting Agency: Meta Vaux Warrick Fuller’s Scrapbook

open access: yesPanorama, 2022
Erika Schneider
doaj   +1 more source

Unburdening the (Dis)Connected Individual? A Digital Disconnection Policy Paradox in Flanders (Belgium)

open access: yesMedia and Communication
The concept of digital disconnection, which refers to limiting digital media use for the sake of one’s well-being, has gained prominence in scholarly and public debates. Compared to a burgeoning digital disconnection industry that commodifies individuals’
Tom De Leyn   +7 more
doaj   +1 more source

A legacy handbook for enterprise [PDF]

open access: yes, 2011
Legacy Handbook reviewing emda's experience of enterprise activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this ...
East Midlands Development Agency, EMDA
core  

Professionalism, Agency, and Market Failures [PDF]

open access: yes, 2016
According to the Market Failures Approach to business ethics, beyond-compliance duties can be derived by employing the same rationale and arguments that justify state regulation of economic conduct.
von Kriegstein, Hasko
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

A legacy handbook for innovation [PDF]

open access: yes, 2011
Legacy Handbook reviewing emda's experience of innovation activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this ...
East Midlands Development Agency, EMDA
core  

“Regulatory Daubert”: A Proposal to Enhance Judicial Review of Agency Science by Incorporating Daubert Principles into Administrative Law [PDF]

open access: yes, 2003
In Daubert v. Merrell Dow Pharmaceuticals Inc, the US Supreme Court empowered federal judges to reject irrelevant or unreliable scientific evidence. Daubert provides a suitable framework for reviewing the quality of agency science and the soundness of ...
Raul, Alan Charles, Dwyer, Julie Zampa
core   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Revising Gerty MacDowell’s Identity and Agency: An Intersectional Feminist Disability Perspective

open access: yesHumanities
Gerty MacDowell’s initial, albeit brief, appearance in James Joyce’s Ulysses has sparked debates regarding her identity and agency. In the critical literature, there are interpretations that characterize Gerty as a woman and disabled person whose actions
Maria Gallego-Ortiz
doaj   +1 more source

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