Results 51 to 60 of about 2,093,874 (309)

The Cost of Rational Agency [PDF]

open access: yes, 1999
The rational agency assumption limits systems to domains of application that have never been observed. Moreover, representing agents as being rational in the sense of maximising utility subject to some well specified constraints renders software systems ...
Moss, Scott
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

AGENCY COST TO DIVIDEND PAYOUT RATIO

open access: yesJurnal Analisis Bisnis Ekonomi, 2017
Penelitian ini dilakukan untuk menguji pengaruh biaya keagenan terhadap kebijakan dividen (dividen payout ratio). Dalam hal ini, biaya keagenan diwakili oleh kepemilikan insider, kepemilikan institusional, collateralizable asset, debt to total assets ...
Nur Imam, Prasetiono Prasetiono
doaj  

PENGHINDARAN PAJAK TERHADAP NILAI PERUSAHAAN DAN BIAYA AGENSI DENGAN TRANSPARANSI INFORMASI SEBAGAI VARIABEL PEMODERASI

open access: yesJurnal Analisis Bisnis Ekonomi, 2018
This study aims to examine the effect of tax avoidance as an independent variable to firm value and agency cost as dependent variable and transparency of information as moderating variable.
Theresa Dina Tarida   +1 more
doaj   +1 more source

DETERMINAN PENGUNGKAPAN VARIASI PERTUMBUHAN LABA ANTAR SEGMEN

open access: yesJurnal Akuntansi Kontemporer, 2020
The results of previous studies regarding the determinants of strategic revelation of differences in segmen earnings growth are still not consistent.
Natalia Christine Putri, Lodovicus Lasdi
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Employee Stock Ownership Plans and Market Stability: A Longitudinal Analysis of Stock Price Crash Risk in China

open access: yesRisks
Reducing stock price crash risk is vital for capital market stability, particularly in emerging economies such as China. This study investigates whether Employee Stock Ownership Plans (ESOPs) can mitigate crash risk by analyzing panel data from A-share ...
Mengfei Liu, Xiyuan Jiang, Xuyan Tong
doaj   +1 more source

Monte Carlo simulation by computer for life-cycle costing [PDF]

open access: yes, 1969
Prediction of behavior and support requirements during the entire life cycle of a system enables accurate cost estimates by using the Monte Carlo simulation by computer.
Gralow, F. H., Larson, W. J.
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

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