Results 51 to 60 of about 257,434 (259)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Effect of Agency Cost on the Relationship between Corporate Governance and Cost of Equity Capital [PDF]
Journal of Asset Management and Financing, 2018 In this paper, the effect of agency cost on the relationship between corporate governance and cost of equity capital is studied. The models for testing hypotheses are multivariate regression model from Chen et al (2011) study.
Farzaneh Heidarpoor +1 more
doaj +1 more source
The social cost of adoption agencies
International Review of Law and Economics, 1986 Abstract The use of adoption agencies to place adoptable children is compared with a market. The lost consumer surplus to potential adopting parents amounts to between $45 million and $1.7 billion per year. In addition, evidence is presented from follow-up studies of adoptions to indicate that social workers do a poorer job of matching parents with ...
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
AGENCY COSTS, RISK SHOCKS, AND INTERNATIONAL CYCLES [PDF]
Macroeconomic Dynamics, 2017 We add agency costs into a two-country, two-good international business-cycle model. In our model, changes in the relative price of investment arise endogenously. Despite the fact that technology shocks are uncorrelated across countries, the relative price of investment is positively correlated across countries in our model, much as it is in detrended ...
Letendre, Marc-André, Wagner, Joel
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
China Accounting and Finance ReviewThis paper explores the association between directors’ and officers’ liability insurance (D&O insurance) and management tone manipulation. This study uses data from A-share listed non-financial companies from 2009 to 2021 as its sample for empirical ...
Wei Xiong +3 more
doaj +1 more source
Agency Costs of Debt in Conglomerate Firms
Journal of Financial and Quantitative Analysis, 2021 AbstractI use an accounting reform to assess the agency cost of debt in diversified firms. Those firms that switch from single to multiple segments following the reform suffer a 12% increase in their bond spread when compared with their stand-alone peers.
openaire +2 more sources