Results 71 to 80 of about 3,083,361 (307)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
R&D, Agency Costs and Capital Structure: International Evidence [PDF]
We examine the impact of R&D intensity and agency costs on the value of firms across 13 economies. We find that R&D adds value while high agency costs reduce value. R&D adds value, however, even when agency costs are high.
Sinclair Davidson, Robert Brooks
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
MathematicsNowadays, the call for sustainable development is becoming stronger in all countries of the world, and environmental, social, and governance (ESG) performance, as a vivid practice of this concept, has gradually received extensive attention from ...
Zhiliang Wu, Shaowei Chen
doaj +1 more source
The Effect of Reporting Convergence toward an Integrated Framework on Financial Reporting Quality and Agency Conflicts [PDF]
بررسیهای حسابداری و حسابرسیObjectiveThere are always incentives for agency problems in firms due to potential conflicts of interest among managers, shareholders, and stakeholders. Therefore, efforts to disclose appropriate and high-quality information are one of the approaches to ...
Hassan Badri Gamchi +3 more
doaj +1 more source
Entrepreneurial Financing, Advice, and Agency Costs [PDF]
This paper studies the interplay between advice and agency costs in entrepreneurial financing. We show that advise may exacerbate agency problems, because the agent may use it at the investor's expense and thereby hurt investors.
Roland Strausz
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
Agency costs in the process of development [PDF]
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Acemoglu, Daron, Zilibotti, Fabrizio
openaire +5 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch +5 more
wiley +1 more source
Deaccessioning and Agency Costs of Free Cash Flow in Manager's Hands: A Formal Model [PDF]
Economic and Business Review, 2014 The problem of agency costs of free cash flow in manager's hands has been firstly noted by Easterbrook and Jensen. We present one of the first attempts to formally model the problem in light of similar situation faced by managers of museums being allowed
Andrej Srakar
doaj